Evidence map›Paper›PMID 33947551›Full record

ReviewMaterials science & engineering. C, Materials for biological applications2021

Recent advances in bioprinting technologies for engineering cardiac tissue.

Tarun Agarwal, Gabriele Maria Fortunato, Sung Yun Hann, Bugra Ayan, Kiran Yellappa Vajanthri, Dario Presutti, Haitao Cui, Alex H P Chan, Marco Costantini, Valentina Onesto and 7 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials science & engineering. C, Materials for biological applications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. 3D Bioprinting Functional Engineered Heart Tissues.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Bioengineering Cell Therapy for Treatment of Peripheral Artery Disease.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Review
  14. Review
  15. Review
  16. Biomaterials for extrusion-based bioprinting and biomedical applications.Frontiers in bioengineering and biotechnology · 2024
    Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Tarun AgarwalDepartment of Biotechnology, Indian Institute of Technology Kharagpur, West Bengal 721302, India.
Gabriele Maria FortunatoResearch Center "E. Piaggio" and Department of Information Engineering, University of Pisa, Largo Lucio Lazzarino 1, 56122 Pisa, Italy.
Sung Yun HannDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.
Bugra AyanDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
Kiran Yellappa VajanthriSchool of Biomedical Engineering, Indian Institute of Technology Banaras Hindu University Varanasi, Uttar Pradesh 221005, India.
Dario PresuttiInstitute of Physical Chemistry - Polish Academy of Sciences, Warsaw, Poland.
Haitao CuiDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.
Alex H P ChanDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
Marco CostantiniInstitute of Physical Chemistry - Polish Academy of Sciences, Warsaw, Poland.
Valentina OnestoInstitute of Nanotechnology, National Research Council (CNR-NANOTEC), Campus Ecotekne, via Monteroni, Lecce 73100, Italy.
Concetta Di NataleCenter for Advanced Biomaterial for Health Care (CABHC), Istituto Italiano di Tecnologia, Naples, Italy; Interdisciplinary Research Centre on Biomaterials (CRIB), University of Naples Federico II, P.leTecchio 80, Naples 80125, Italy.
Ngan F HuangDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
Pooyan MakvandiCenter for Materials Interface, Istituto Italiano di Tecnologia, Pontedera 56025, Pisa, Italy.
Majid ShabaniCenter for Materials Interface, Istituto Italiano di Tecnologia, Pontedera 56025, Pisa, Italy.
Tapas Kumar MaitiDepartment of Biotechnology, Indian Institute of Technology Kharagpur, West Bengal 721302, India. Electronic address: tkmaiti@hijli.iitkgp.ernet.in.
Lijie Grace ZhangDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA; Department of Electrical and Computer Engineering, The George Washington University, Washington, DC 20052, USA; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA; Department of Medicine, The George Washington University, Washington, DC 20052, USA. Electronic address: lgzhang@email.gwu.edu.
Carmelo De MariaResearch Center "E. Piaggio" and Department of Information Engineering, University of Pisa, Largo Lucio Lazzarino 1, 56122 Pisa, Italy. Electronic address: carmelo.demaria@unipi.it.

Funding

Aligned Nanofibrillar Scaffolds Enhance Angiogenesis and Viability in Ischemia: Sex Differences Administrative SupplementR01HL127113 · NHLBI · STANFORD UNIVERSITY · PI HUANG, NGAN F. · 2016 to 2020
$2.5M
Engineered matrix microarrays to enhance the regenerative potential of iPSC-derived endothelial cellsR01HL142718 · NHLBI · STANFORD UNIVERSITY · PI HEILSHORN, SARAH C, HUANG, NGAN F. · 2018 to 2021
$1.6M
BLRD VA I01 BX004259NHLBI NIH HHS R01 HL127113NHLBI NIH HHS R01 HL142718RRD VA I01 RX001222
6 · The paper itself

Abstract

Annually increasing incidence of cardiac-related disorders and cardiac tissue's minimal regenerative capacity have motivated the researchers to explore effective therapeutic strategies. In the recent years, bioprinting technologies have witnessed a great wave of enthusiasm and have undergone steady advancements over a short period, opening the possibilities for recreating engineered functional cardiac tissue models for regenerative and diagnostic applications. With this perspective, the current review delineates recent developments in the sphere of engineered cardiac tissue fabrication, using traditional and advanced bioprinting strategies. The review also highlights different printing ink formulations, available cellular opportunities, and aspects of personalized medicines in the context of cardiac tissue engineering and bioprinting. On a concluding note, current challenges and prospects for further advancements are also discussed.

Indexed as

BioprintingHeartInkPrinting, Three-DimensionalTissue EngineeringBioprintingCardiac tissue engineeringCardio-inductive microenvironmentStem cells

Identifiers

PMID33947551
PMCPMC9381603

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.