Evidence map›Paper›PMID 33947371›Full record

ArticleBMC pediatrics2021

A Niemann-pick C1 disease child with BCG-itis: a case report and analysis.

Jing-Jing Lin, Xu-Hui Liu, Lu Xia, Yan-Ling Feng, Xiu-Hong Xi, Shui-Hua Lu

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jing-Jing LinShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Xu-Hui LiuShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Lu XiaShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yan-Ling FengShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Xiu-Hong XiShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Shui-Hua LuShanghai Public Health Clinical Center, Fudan University, Shanghai, China. tubercle@shphc.org.cn.
Shanghai Public Health Clinical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNiemann-Pick C disease is a rare autosomal recessive lysosomal lipid storage disorder. Some primary immunodeficiency diseases patients developed regional disease or disseminated disease after vaccinating BCG. It is unclear whether NPC gene deficiency is associated with Mycobacteria infection. CASE PRESENTATION: We report and discuss a case of a child who presented at the age of 6 months with NPC1 and BCG-itis. The patient was treated with Miglustat and the symptom of lymphadenopathy was improved.

conclusionsWe reasonably speculate that NPC1 is a susceptibility gene of Mtb infection and mainly affects innate immunity. Once diagnosed, the infant should not be vaccinated with BCG and early treated.

Indexed as

BCG VaccineNiemann-Pick Disease, Type CChildFamilyHumansInfantBCG VaccineBCG-itisCase reportNiemann‐pick C1 disease

Identifiers

PMID33947371
PMCPMC8094597
OpenAlexW3159225914

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.