ArticleBMC genomics2021
Transcriptome of different fruiting stages in the cultivated mushroom Cyclocybe aegerita suggests a complex regulation of fruiting and reveals enzymes putatively involved in fungal oxylipin biosynthesis.
Article in BMC genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 33 citations in OpenAlex.
- Transcriptomic Profiling of Developmental Stages and Screening of Candidate Genes inJournal of fungi (Basel, Switzerland) · 2026Article
- Quality characteristics and volatile organic compound profiling of yellow mushrooms at different cap opening stages.Scientific reports · 2025Article
- Identification of Critical Candidate Genes Controlling Monokaryon Fruiting inJournal of fungi (Basel, Switzerland) · 2025Article
- Antifungal Volatile Organic Compounds fromJournal of fungi (Basel, Switzerland) · 2025Article
- Bifunctional Sesquiterpene/Diterpene Synthase Agr2 fromACS chemical biology · 2024Article
- Invasive Californian death caps develop mushrooms unisexually and bisexually.Nature communications · 2023Article
- Lessons on fruiting body morphogenesis from genomes and transcriptomes ofStudies in mycology · 2023Article
- Transcriptome Profiling Reveals Candidate Genes Related to Stipe Gradient Elongation ofJournal of fungi (Basel, Switzerland) · 2022Article
- The Role of Chromatin and Transcriptional Control in the Formation of Sexual Fruiting Bodies in Fungi.Microbiology and molecular biology reviews : MMBR · 2022Review
- Organic Nitrogen Supplementation Increases Vegetative and Reproductive Biomass in a Versatile White Rot Fungus.Journal of fungi (Basel, Switzerland) · 2022Article
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- The Role of 12/15-Lipoxygenase and Its Various Metabolites Generated from Multiple Polyunsaturated Fatty Acids as Substrates in Inflammatory Responses.BioMed research international · 2022Review
- A Transcriptomic Atlas of the Ectomycorrhizal FungusMicroorganisms · 2021Article
- Heat stress in macrofungi: effects and response mechanisms.Applied microbiology and biotechnology · 2021Review
- Transcriptional response of mushrooms to artificial sun exposure.Ecology and evolution · 2021Article
- The Pacific Tree-Parasitic FungusJournal of fungi (Basel, Switzerland) · 2021Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCyclocybe aegerita (syn. Agrocybe aegerita) is a commercially cultivated mushroom. Its archetypal agaric morphology and its ability to undergo its whole life cycle under laboratory conditions makes this fungus a well-suited model for studying fruiting body (basidiome, basidiocarp) development. To elucidate the so far barely understood biosynthesis of fungal volatiles, alterations in the transcriptome during different developmental stages of C. aegerita were analyzed and combined with changes in the volatile profile during its different fruiting stages.
resultsA transcriptomic study at seven points in time during fruiting body development of C. aegerita with seven mycelial and five fruiting body stages was conducted. Differential gene expression was observed for genes involved in fungal fruiting body formation showing interesting transcriptional patterns and correlations of these fruiting-related genes with the developmental stages. Combining transcriptome and volatilome data, enzymes putatively involved in the biosynthesis of C8 oxylipins in C. aegerita including lipoxygenases (LOXs), dioxygenases (DOXs), hydroperoxide lyases (HPLs), alcohol dehydrogenases (ADHs) and ene-reductases could be identified. Furthermore, we were able to localize the mycelium as the main source for sesquiterpenes predominant during sporulation in the headspace of C. aegerita cultures. In contrast, changes in the C8 profile detected in late stages of development are probably due to the activity of enzymes located in the fruiting bodies.
conclusionsIn this study, the combination of volatilome and transcriptome data of C. aegerita revealed interesting candidates both for functional genetics-based analysis of fruiting-related genes and for prospective enzyme characterization studies to further elucidate the so far barely understood biosynthesis of fungal C8 oxylipins.
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