Evidence map›Paper›PMID 33947253›Full record

ArticleBrain connectivity2021

Combined Model of Aggregation and Network Diffusion Recapitulates Alzheimer's Regional Tau-Positron Emission Tomography.

Ashish Raj, Veronica Tora, Xiao Gao, Hanna Cho, Jae Yong Choi, Young Hoon Ryu, Chul Hyoung Lyoo, Bruno Franchi

Abstract read
In one paragraph

Article in Brain connectivity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. A network-level transport model of tau progression in the Alzheimer's brain.Mathematical medicine and biology : a journal of the IMA · 2025
    Article
  7. Review
  8. Article
  9. Connectome-based biophysics models of Alzheimer's disease diagnosis and prognosis.Translational research : the journal of laboratory and clinical medicine · 2023
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ashish RajDepartment of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA.ORCID 0000-0003-2414-2444
Veronica ToraDipartimento di Matematica, Universita' di Bologna, Bologna, Italy.
Xiao GaoDepartment of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA.
Hanna ChoDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seodaemun-gu, Republic of Korea.
Jae Yong ChoiDepartment of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seodaemun-gu, Republic of Korea.
Young Hoon RyuDepartment of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seodaemun-gu, Republic of Korea.
Chul Hyoung LyooDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seodaemun-gu, Republic of Korea.
Bruno FranchiDipartimento di Matematica, Universita' di Bologna, Bologna, Italy.

Funding

Network Modelling of Multimodal Dynamics in Alzheimer’s Disease and DementiaRF1AG062196 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NAGARAJAN, SRIKANTAN S., RAJ, ASHISH · 2019 to 2019
$3.0M
Predictive model of spread of Parkinson's pathology using network diffusionR01NS092802 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GUPTA, AJAY, RAJ, ASHISH · 2016 to 2020
$2.8M
Understanding the dynamic interactions between tau pathology and microglia-mediated inflammation in Alzheimer's DiseaseR56AG064873 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI GUPTA, AJAY, RAJ, ASHISH · 2019 to 2019
$771k
NIA NIH HHS R56 AG064873NIA NIH HHS RF1 AG062196NINDS NIH HHS R01 NS092802
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseConnectomeBrainHumansPositron-Emission Tomographytau Proteinstau ProteinsAlzheimer's diseasegraphsnetwork diffusionprotein aggregationSmoluchowski equationstrans-neuronal spreadτ-PET

Identifiers

PMID33947253
PMCPMC8817716

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.