Evidence map›Paper›PMID 33947162›Full record

ArticleBiomolecules2021

Green Production of Cladribine by Using Immobilized

Cintia Wanda Rivero, Natalia Soledad García, Jesús Fernández-Lucas, Lorena Betancor, Gustavo Pablo Romanelli, Jorge Abel Trelles

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Magnetic Multi-Enzymatic System for Cladribine Manufacturing.International journal of molecular sciences · 2022
    Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Cintia Wanda RiveroLaboratory of Sustainable Biotechnology (LIBioS), National University of Quilmes, Bernal B1876BXD, Argentina.
Natalia Soledad GarcíaLaboratory of Sustainable Biotechnology (LIBioS), National University of Quilmes, Bernal B1876BXD, Argentina.
Jesús Fernández-LucasApplied Biotechnology Group, Biomedical Science School, Universidad Europea de Madrid, 28670 Villaviciosa de Odón, Spain.ORCID 0000-0001-7045-8306
Lorena BetancorBiotechnology Laboratory, Faculty of Engineering, Universidad ORT Uruguay, Montevideo 11100, Uruguay.
Gustavo Pablo RomanelliCenter for Research and Development in Applied Sciences, National University of La Plata, La Plata B1900AJK, Argentina.
Jorge Abel TrellesLaboratory of Sustainable Biotechnology (LIBioS), National University of Quilmes, Bernal B1876BXD, Argentina.
National University of Quilmes · ARUniversidad Nacional de La Plata · ARUniversidad ORT Uruguay · UYUniversity of the Coast · CO

Funding

Agencia Nacional de Promoción Científica y Tecnológica PICT 2014-3438Consejo Nacional de Investigaciones Científicas y Técnicas PIP 2014- 11220130100805COEuropean University of Madrid 2020/UEM42Fundación Banco Santander XSAN192006Universidad Nacional de Quilmes PUNQ 1305/19, PPROF 2017-EXPTE.895/18
6 · The paper itself

Abstract

Nowadays, enzyme-mediated processes offer an eco-friendly and efficient alternative to the traditional multistep and environmentally harmful chemical processes. Herein we report the enzymatic synthesis of cladribine by a novel 2'-deoxyribosyltransferase (NDT)-based combined biocatalyst. To this end,

Indexed as

Bacterial ProteinsBiocatalysisCladribineEnzymes, ImmobilizedEnzyme StabilityGlutaralGreen Chemistry TechnologyHydrogen-Ion ConcentrationLactobacillus delbrueckiiSilicon DioxideTemperatureTransferasesBacterial ProteinsCladribineEnzymes, ImmobilizedGlutaralSilicon DioxideTransferasesantineoplastic drugbiomimetic silicacalcium alginateentrapmentenzyme immobilizationglutaraldehyde

Identifiers

PMID33947162
PMCPMC8146660
OpenAlexW3159597183

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.