Evidence map›Paper›PMID 33947136›Full record

ArticleGenes2021

Changes in Allele Frequencies When Different Genomic Coancestry Matrices Are Used for Maintaining Genetic Diversity.

Elisabeth Morales-González, Jesús Fernández, Ricardo Pong-Wong, Miguel Ángel Toro, Beatriz Villanueva

Abstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Elisabeth Morales-GonzálezDepartamento de Mejora Genética Animal, INIA, Ctra. de La Coruña, km 7.5, 28040 Madrid, Spain.ORCID 0000-0002-5614-5044
Jesús FernándezDepartamento de Mejora Genética Animal, INIA, Ctra. de La Coruña, km 7.5, 28040 Madrid, Spain.ORCID 0000-0001-8269-1893
Ricardo Pong-WongGenetics and Genomics, The Roslin Institute and R(D)SVS of the University of Edinburgh, Midlothian EH25 9RG, Roslin, UK.
Miguel Ángel ToroDepartamento de Producción Agraria, Universidad Politécnica de Madrid, 28040 Madrid, Spain.ORCID 0000-0001-7460-2483
Beatriz VillanuevaDepartamento de Mejora Genética Animal, INIA, Ctra. de La Coruña, km 7.5, 28040 Madrid, Spain.

Funding

Biotechnology and Biological Sciences Research Council BBS/E/D/30002275
6 · The paper itself

Abstract

A main objective in conservation programs is to maintain genetic variability. This can be achieved using the Optimal Contributions (OC) method that optimizes the contributions of candidates to the next generation by minimizing the global coancestry. However, it has been argued that maintaining allele frequencies is also important. Different genomic coancestry matrices can be used on OC and the choice of the matrix will have an impact not only on the genetic variability maintained, but also on the change in allele frequencies. The objective of this study was to evaluate, through stochastic simulations, the genetic variability maintained and the trajectory of allele frequencies when using two different genomic coancestry matrices in OC to minimize the loss of diversity: (i) the matrix based on deviations of the observed number of alleles shared between two individuals from the expected numbers under Hardy-Weinberg equilibrium (

Indexed as

Gene FrequencyModels, GeneticPhylogenyPolymorphism, GeneticAnimalsEndangered SpeciesGenetic FitnessLinkage Disequilibriumallele frequenciesgenetic diversitygenomic coancestry matrixoptimal contributions

Identifiers

PMID33947136
PMCPMC8146037

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.