Evidence map›Paper›PMID 33946982›Full record

ReviewJournal of personalized medicine2021

Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example.

Bram Peter Prins, Liis Leitsalu, Katri Pärna, Krista Fischer, Andres Metspalu, Toomas Haller, Harold Snieder

Open access · goldAbstract readReview
In one paragraph

Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Bram Peter PrinsMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.ORCID 0000-0001-5774-034X
Liis LeitsaluInstitute of Genomics, University of Tartu, 51010 Tartu, Estonia.ORCID 0000-0001-7616-5440
Katri PärnaInstitute of Genomics, University of Tartu, 51010 Tartu, Estonia.ORCID 0000-0002-0013-6077
Krista FischerInstitute of Genomics, University of Tartu, 51010 Tartu, Estonia.ORCID 0000-0002-3521-0599
Andres MetspaluInstitute of Genomics, University of Tartu, 51010 Tartu, Estonia.
Toomas HallerInstitute of Genomics, University of Tartu, 51010 Tartu, Estonia.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-1949-2298
University of Tartu · EEUniversity Medical Center Groningen · NLUniversity of Cambridge · GB

Funding

British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Estonian Research Council grant PUT PRG555Estonian Research Council grant PUT PRG687European Union through Horizon 2020 grant 633589European Union through Horizon 2020 grant 777107Medical Research Council MR/L003120/1UK Medical Research Council MR/L003120/1
6 · The paper itself

Abstract

The current paradigm of personalized medicine envisages the use of genomic data to provide predictive information on the health course of an individual with the aim of prevention and individualized care. However, substantial efforts are required to realize the concept: enhanced genetic discoveries, translation into intervention strategies, and a systematic implementation in healthcare. Here we review how further genetic discoveries are improving personalized prediction and advance functional insights into the link between genetics and disease. In the second part we give our perspective on the way these advances in genomic research will transform the future of personalized prevention and medicine using Estonia as a primer.

Indexed as

biobankEstoniagenetic discoverygenomic medicinepatient communicationreturn of results

Identifiers

PMID33946982
PMCPMC8145318
OpenAlexW3157814757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.