ArticleJournal of clinical medicine2021
Neutrophil-to-Lymphocyte Ratio, a Novel Inflammatory Marker, as a Predictor of Bipolar Type in Depressed Patients: A Quest for Biological Markers.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Complete blood count-based inflammatory ratios in people with bipolar disorder: a systematic review and meta-analysis of neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios.European psychiatry : the journal of the Association of European Psychiatrists · 2026Pooled it
- Peripheral biochemical parameters for discrimination between bipolar disorder and major depressive disorder in female patients of reproductive age: a CRP-stratified exploratory study.BMC psychiatry · 2026Article
- Complete blood count-based inflammation indexes and symptom severity in people with bipolar disorder: an analysis based on structural equation modelling.European archives of psychiatry and clinical neuroscience · 2026Article
- Differential diagnosis of bipolar II disorder and major depressive disorder: Integrating multimodal approaches to overcome clinical challenges.World journal of psychiatry · 2026Review
- A taxon-centered review of bacterial shifts in psychiatric disorders.Frontiers in psychiatry · 2026Review
- Article
- Blue light treatment of psychiatric disorders: relationships with systemic inflammation, lipid metabolism, and clinical symptoms.BMC psychiatry · 2025Article
- Evaluation of Pan-immune Inflammation Value and Systemic Immune Inflammation Index in Different Mood Episodes of Bipolar Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- The systemic immune-inflammation index (SII) as a biomarker for depression in a community sample of adolescents.Comprehensive psychoneuroendocrinology · 2025Article
- Tracking complete blood count-derived indices during transition to euthymia in bipolar disorder: a longitudinal study.Biomarkers in medicine · 2025Article
- Human Papillomavirus Positivity and Cognitive Function in Older U.S. Adults: A Cross-Sectional Population-Based Study.Pathogens (Basel, Switzerland) · 2025Article
- Possible Significance of Neutrophil-Hemoglobin Ratio in Differentiating Progressive Supranuclear Palsy from Depression: A Pilot Study.Diseases (Basel, Switzerland) · 2025Article
- Immune indicators and depression in adolescents: Associations with monocytes, lymphocytes, and direct bilirubin.World journal of psychiatry · 2025Article
- Clinical predictors of short-term treatment response in stupor: a retrospective study.Frontiers in psychiatry · 2025Article
- Electroconvulsive therapy for obsessive-compulsive disorder: clinical efficacy and predictive role of inflammatory markers.Frontiers in psychiatry · 2025Article
- Systemic Immune-Inflammatory Index and Systemic Inflammatory Response Index in the Assessment of Multiple Organ Dysfunction Syndrome Caused by Wasp Stings.Journal of inflammation research · 2025Article
- Neutrophil-to-lymphocyte, platelet-to-lymphocyte ratios and systemic immune-inflammation index in patients with post-traumatic stress disorder.BMC psychiatry · 2024Article
- How to predict postoperative delirium in geriatric patients with hip fracture as soon as possible? A retrospective study.BMC surgery · 2024Article
- Relative value of novel systemic immune-inflammatory indices and classical hematological parameters in predicting depression, suicide attempts and treatment response.Scientific reports · 2024Article
- Peripheral biomarkers to differentiate bipolar depression from major depressive disorder: a real-world retrospective study.BMC psychiatry · 2024Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(1) Background: Recent research suggests inflammation as a factor involved in the pathophysiology of mood disorders. Neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR), platelet-to-lymphocyte (PLR), and systemic immune-inflammatory (SII) index ratios have been studied as peripheral markers of inflammation in bipolar and major depressive disorders. The purpose of this study is to comparatively analyze these inflammatory ratios among manic episodes of bipolar disorder, bipolar depression and unipolar depression. (2) Methods: 182 patients were retrospectively included in the study and divided into three groups: 65 manic patients, 34 patients with bipolar depression, and 83 unipolar depressive patients. White blood cells, neutrophils, monocytes, lymphocytes, and platelets were retrieved from the patients' database. NLR, MLR, PLR, and SII index were calculated using these parameters. (3) Results: Patients with manic episodes had elevated NLR (
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