Evidence map›Paper›PMID 33946865›Full record

ArticleGenes2021

Investigating Olfactory Gene Variation and Odour Identification in Older Adults.

Siddharth Raj, Anbupalam Thalamuthu, Nicola J Armstrong, Margaret J Wright, John B Kwok, Julian N Trollor, David Ames, Peter R Schofield, Henry Brodaty, Perminder S Sachdev and 1 more

Open access · goldAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Siddharth RajCentre for Healthy Brain Ageing, Faculty of Medicine, School of Psychiatry, University of New South Wales (UNSW), Sydney, NSW 2031, Australia.ORCID 0000-0001-8956-6307
Anbupalam ThalamuthuCentre for Healthy Brain Ageing, Faculty of Medicine, School of Psychiatry, University of New South Wales (UNSW), Sydney, NSW 2031, Australia.ORCID 0000-0002-7114-1260
Nicola J ArmstrongDepartment of Mathematics and Statistics, Curtin University, Perth, WA 6102, Australia.ORCID 0000-0002-4477-293X
Margaret J WrightQueensland Brain Institute, University of Queensland, St. Lucia, QLD 4072, Australia.
John B KwokSchool of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia.
Julian N TrollorCentre for Healthy Brain Ageing, Faculty of Medicine, School of Psychiatry, University of New South Wales (UNSW), Sydney, NSW 2031, Australia.ORCID 0000-0002-7685-2977
David AmesNational Ageing Research Institute, Parkville, VIC 3052, Australia.
Peter R SchofieldNeuroscience Research Australia, Sydney, NSW 2031, Australia.ORCID 0000-0003-2967-9662
Henry BrodatyCentre for Healthy Brain Ageing, Faculty of Medicine, School of Psychiatry, University of New South Wales (UNSW), Sydney, NSW 2031, Australia.ORCID 0000-0001-9487-6617
Perminder S SachdevCentre for Healthy Brain Ageing, Faculty of Medicine, School of Psychiatry, University of New South Wales (UNSW), Sydney, NSW 2031, Australia.
Karen A MatherCentre for Healthy Brain Ageing, Faculty of Medicine, School of Psychiatry, University of New South Wales (UNSW), Sydney, NSW 2031, Australia.
UNSW Sydney · AUCurtin University · AUThe University of Melbourne · AUThe University of Queensland · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ageing is associated with a decrease in odour identification. Additionally, deficits in olfaction have been linked to age-related disease and mortality. Heritability studies suggest genetic variation contributes to olfactory identification. The olfactory receptor (OR) gene family is the largest in the human genome and responsible for overall odour identification. In this study, we sought to find olfactory gene family variants associated with individual and overall odour identification and to examine the relationships between polygenic risk scores (PRS) for olfactory-related phenotypes and olfaction. Participants were Caucasian older adults from the Sydney Memory and Ageing Study and the Older Australian Twins Study with genome-wide genotyping data (

Indexed as

Olfactory PerceptionPolymorphism, Single NucleotideSmellAgedAged, 80 and overAgingFemaleHumansMaleReceptors, OdorantReceptors, Odorantageinggeneticsodour identificationolfaction

Identifiers

PMID33946865
PMCPMC8145954
OpenAlexW3158528530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.