Evidence map›Paper›PMID 33946806›Full record

ReviewMolecules (Basel, Switzerland)2021

Computational Approaches: An Underutilized Tool in the Quest to Elucidate Radical SAM Dynamics.

Tamra C Blue, Katherine M Davis

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Special Issue "Protein Methyltransferases in Human Health and Diseases".International journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tamra C BlueDepartment of Chemistry, Emory University, 1515 Dickey Dr, Atlanta, GA 30322, USA.ORCID 0000-0002-4026-7274
Katherine M DavisDepartment of Chemistry, Emory University, 1515 Dickey Dr, Atlanta, GA 30322, USA.ORCID 0000-0002-0258-8907

Funding

Learning the Steps to Metalloenzyme ChoreographyR00GM129460 · NIGMS · EMORY UNIVERSITY · PI DAVIS, KATHERINE MARIE · 2020 to 2022
$747k
NIGMS NIH HHS R00 GM129460NIH HHS 4R00GM129460
6 · The paper itself

Abstract

Enzymes are biological catalysts whose dynamics enable their reactivity. Visualizing conformational changes, in particular, is technically challenging, and little is known about these crucial atomic motions. This is especially problematic for understanding the functional diversity associated with the radical

Indexed as

Models, MolecularAcetyltransferasesDensity Functional TheoryMolecular ConformationMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureProtein BindingQuantum TheoryS-AdenosylmethionineVitamin B 12Acetyltransferasespyruvate formate-lyase activating enzymeS-AdenosylmethionineVitamin B 12computationalDFTdockingdynamicsMDQM/MMradical SAM enzymes

Identifiers

PMID33946806
PMCPMC8124187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.