ReviewAnimals : an open access journal from MDPI2021
Recent Advances in Understanding the Influence of Zinc, Copper, and Manganese on the Gastrointestinal Environment of Pigs and Poultry.
Review in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
- Zinc-Mediated Modulation of Host-Pathogen Interactions in Poultry: Implications for Salmonella Control and Trace Element Biology.Biological trace element research · 2026Review
- Novel in ovo application of green-synthesized FeScientific reports · 2026Article
- Early-Phase Response of Broiler Breeders to 25-Hydroxyvitamin DAnimals : an open access journal from MDPI · 2026Article
- Trace mineral sources affect oxidized oil induced intestinal damage in chickens by modulation of gut microbiota and short-chain fatty acid metabolism.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Replacement of added trace minerals (zinc, copper, iron, and manganese) by a consensus bacterial 6-phytase variant in weaned pigs fed an all-vegetable diet.Journal of animal science · 2026Article
- Effects of Zeolite on Virulence Gene Content in Avian PathogenicVeterinary medicine international · 2026Article
- Dietary zinc, manganese and copper combination in sulphate or amino acid chelate forms impacts laying performance and intestinal morphology in late-phase laying hens.Tropical animal health and production · 2025Article
- Synergistic Effects of Hydroxychloride and Organic Zinc on Performance, Carcass Characteristics, Liver and Tibia Mineral Profiles of Broiler Chickens.Biological trace element research · 2025Article
- Monovalent Copper Oxide in Broiler Nutrition: Effects on Performance, Intestinal Lesions, and Oocyst Shedding During MildVeterinary sciences · 2025Article
- Anticoccidial activities of a multicomplex mineral-based diet in broilers infected with Eimeria acervulina.Parasites, hosts and diseases · 2025Article
- Effect of Replacing Inorganic Copper, Zinc, and Selenium with Chelated Minerals on Productive Performance, Nutrient Utilization, Tibia Morphology, and Intestinal Histology of Growing Japanese Quail (The journal of poultry science · 2025Article
- Potential mechanisms of zinc sulfate in inhibiting porcine reproductive and respiratory syndrome virus replication: attenuation of oxidative stress, inflammatory response, and apoptosis.Frontiers in veterinary science · 2025Article
- Potentiated zinc and monovalent copper oxide as dietary supplements for weanling piglets: effects on systemic and mucosal immunity, gut permeability, and fecal microbiota composition.Frontiers in veterinary science · 2025Article
- Comparative Effects of Including Inorganic, Organic, and Hydroxy Zinc Sources on Growth Development, Egg Quality, Mineral Excretion, and Bone Health of Laying Quails.Biological trace element research · 2024Article
- Article
- Novel feed additive delivers antimicrobial copper and influences fecal microbiota in pigs.Microbiology spectrum · 2024Article
- Impact of zinc supplementation on phenotypic antimicrobial resistance of fecal commensal bacteria from pre-weaned dairy calves.Scientific reports · 2024Article
- DecodingFrontiers in microbiology · 2024Article
- Multi-omics unveils tryptophan metabolic pathway as a key pathway influencing residual feed intake in Duroc swine.Frontiers in veterinary science · 2024Article
- Crosstalk between trace elements and T-cell immunity during early-life health in pigs.Science China. Life sciences · 2023Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc, copper, and manganese are prominent essential trace (or micro) minerals, being required in small, but adequate, amounts by pigs and poultry for normal biological functioning. Feed is a source of trace minerals for pigs and poultry but variable bioavailability in typical feed ingredients means that supplementation with low-cost oxides and sulphates has become common practice. Such trace mineral supplementation often provides significant 'safety margins', while copper and zinc have been supplemented at supra-nutritional (or pharmacological) levels to improve health and/or growth performance. Regulatory mechanisms ensure that much of this oversupply is excreted by the host into the environment, which can be toxic to plants and microorganisms or promote antimicrobial resistance in microbes, and thus supplying trace minerals more precisely to pigs and poultry is necessary. The gastrointestinal tract is thus central to the maintenance of trace mineral homeostasis and the provision of supra-nutritional or pharmacological levels is associated with modification of the gut environment, such as the microbiome. This review, therefore, considers recent advances in understanding the influence of zinc, copper, and manganese on the gastrointestinal environment of pigs and poultry, including more novel, alternative sources seeking to maintain supra-nutritional benefits with minimal environmental impact.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.