Evidence map›Paper›PMID 33946612›Full record

ArticleBiomedicines2021

Reduced

Cecilia M Prêle, Thomas Iosifidis, Robin J McAnulty, David R Pearce, Bahareh Badrian, Tylah Miles, Sarra E Jamieson, Matthias Ernst, Philip J Thompson, Geoffrey J Laurent and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Cecilia M PrêleInstitute for Respiratory Health, Nedland 6009, WA, Australia.
Thomas IosifidisInstitute for Respiratory Health, Nedland 6009, WA, Australia.
Robin J McAnultyCentre for Inflammation and Tissue Repair, Rayne Institute, Department of Medicine, University College London, London WC1E 6JJ, UK.ORCID 0000-0003-1936-4245
David R PearceCentre for Inflammation and Tissue Repair, Rayne Institute, Department of Medicine, University College London, London WC1E 6JJ, UK.
Bahareh BadrianInstitute for Respiratory Health, Nedland 6009, WA, Australia.
Tylah MilesInstitute for Respiratory Health, Nedland 6009, WA, Australia.
Sarra E JamiesonTelethon Kids Institute and Centre for Child Health Research, University of Western Australia, Nedlands 6009, WA, Australia.
Matthias ErnstOlivia Newton-John Cancer Research Institute, Heidelberg 3084, Vic, Australia.
Philip J ThompsonInstitute for Respiratory Health, Nedland 6009, WA, Australia.
Geoffrey J LaurentInstitute for Respiratory Health, Nedland 6009, WA, Australia.
Darryl A KnightFaculty of Medicine, University of British Columbia (UBC), Vancouver, BC V6Z 1Y5, Canada.
Steven E MutsaersInstitute for Respiratory Health, Nedland 6009, WA, Australia.ORCID 0000-0002-2615-8338
Institute for Respiratory Health · AUThe University of Western Australia · AUUniversity College London · GBOlivia Newton-John Cancer Wellness & Research Centre · AUThe Kids Research Institute Australia · AUUniversity of British Columbia · CA

Funding

CSRD VA 1National Health and Medical Research Council 458703, 458543
6 · The paper itself

Abstract

The interleukin (IL)-6 family of cytokines and exaggerated signal transducer and activator of transcription (STAT)3 signaling is implicated in idiopathic pulmonary fibrosis (IPF) pathogenesis, but the mechanisms regulating STAT3 expression and function are unknown. Suppressor of cytokine signaling (SOCS)1 and SOCS3 block STAT3, and low SOCS1 levels have been reported in IPF fibroblasts and shown to facilitate collagen production. Fibroblasts and lung tissue from IPF patients and controls were used to examine the mechanisms underlying SOCS1 down-regulation in IPF. A significant reduction in basal

Indexed as

fibroblastfibrosisJak/STAT pathwayL-6miR155SOCS1

Identifiers

PMID33946612
PMCPMC8147237
OpenAlexW3159886782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.