Evidence map›Paper›PMID 33946594›Full record

ArticleGenes2021

Sensitivity to Immune Checkpoint Blockade in Advanced Non-Small Cell Lung Cancer Patients with

Giulio Metro, Sara Baglivo, Guido Bellezza, Martina Mandarano, Alessio Gili, Giovanni Marchetti, Marco Toraldo, Carmen Molica, Maria Sole Reda, Francesca Romana Tofanetti and 13 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. A real‑world study of clinical characteristics, treatment sequence and outcomes of patients with non-small cell lung cancer and EGFR exon 20 insertion mutations.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  4. Article
  5. Review
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  7. Article
  8. Article
  9. Article
  10. Review
  11. Real-World Response and Outcomes in Patients With NSCLC WithJTO clinical and research reports · 2023
    Article
  12. Translational lung cancer research · 2023
    Review
  13. [Advances in the Treatment of EGFR Exon 20ins Mutant NSCLC].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2023
    Article
  14. Article
  15. Advances in the management of non-small-cell lung cancer harbouringTherapeutic advances in medical oncology · 2023
    Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. JTO clinical and research reports · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 1 country.

Giulio MetroMedical Oncology, Santa Maria della Misericordia Hospital, via Dottori 1, 06156 Perugia, Italy.
Sara BaglivoMedical Oncology, Santa Maria della Misericordia Hospital, via Dottori 1, 06156 Perugia, Italy.ORCID 0000-0002-4136-0577
Guido BellezzaSection of Anatomic Pathology and Histology, Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi 1, 06132 Perugia, Italy.
Martina MandaranoSection of Anatomic Pathology and Histology, Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi 1, 06132 Perugia, Italy.ORCID 0000-0001-5019-4825
Alessio GiliPublic Health Section, Department of Experimental Medicine, University of Perugia, Piazza Lucio Severi 1, 06132 Perugia, Italy.ORCID 0000-0002-4359-5193
Giovanni MarchettiDivision of Pathology, Santa Maria Hospital, via Tristano di Joannuccio 1, 05100 Terni, Italy.
Marco ToraldoDivision of Pathology, San Giovanni Battista Hospital, via Massimo Arcamone, 06034 Foligno, Italy.
Carmen MolicaMedical Oncology, Santa Maria della Misericordia Hospital, via Dottori 1, 06156 Perugia, Italy.
Maria Sole RedaMedical Oncology, Santa Maria della Misericordia Hospital, via Dottori 1, 06156 Perugia, Italy.
Francesca Romana TofanettiMedical Oncology, Santa Maria della Misericordia Hospital, via Dottori 1, 06156 Perugia, Italy.
Annamaria SiggillinoMedical Oncology, Santa Maria della Misericordia Hospital, via Dottori 1, 06156 Perugia, Italy.
Enrico ProsperiDivision of Pathology, Città di Castello Hospital, Via Luigi Angelini 10, 06012 Città di Castello, Italy.
Antonella GigliettiHematology and Oncology Unit, San Giovanni Battista Hospital, via Massimo Arcamone, 06034 Foligno, Italy.
Bruna Di GirolamoOncologic Day Hospital, Santa Maria della Stella Hospital, Località Ciconia, 05018 Orvieto, Italy.
Miriam GaraffaMedical Oncology, Santa Maria della Misericordia Hospital, via Dottori 1, 06156 Perugia, Italy.
Francesca MarasciuloMedical Oncology, Santa Maria della Misericordia Hospital, via Dottori 1, 06156 Perugia, Italy.
Vincenzo MinottiMedical Oncology, Santa Maria della Misericordia Hospital, via Dottori 1, 06156 Perugia, Italy.
Marco GunnelliniMedical Oncology, Gubbio and Gualdo Tadino Hospital, Largo Unità d'Italia, 06024 Branca, Italy.ORCID 0000-0002-5583-4892
Annalisa GuidaMedical Oncology, Santa Maria Hospital, via Tristano di Joannuccio 1, 05100 Terni, Italy.
Monica SassiHematology and Oncology Unit, San Giovanni Battista Hospital, via Massimo Arcamone, 06034 Foligno, Italy.
Angelo SidoniSection of Anatomic Pathology and Histology, Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi 1, 06132 Perugia, Italy.
Fausto RoilaMedical Oncology, Santa Maria della Misericordia Hospital, University of Perugia, Piazza Lucio Severi 1, 06132 Perugia, Italy.
Vienna LudoviniMedical Oncology, Santa Maria della Misericordia Hospital, via Dottori 1, 06156 Perugia, Italy.ORCID 0000-0003-2524-5824
University of Perugia · ITAzienda Ospedaliero Universitaria San Giovanni Battista · ITSanta Maria Nuova Hospital · ITCittà di Castello Hospital · ITCTO Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Besides platinum-based chemotherapy, no established treatment option exists for advanced non-small-cell lung cancer (NSCLC) patients with

Indexed as

Drug Resistance, NeoplasmAgedBiomarkers, TumorCarcinoma, Non-Small-Cell LungErbB ReceptorsFemaleHumansImmune Checkpoint InhibitorsLung NeoplasmsMaleMiddle AgedMutagenesis, InsertionalBiomarkers, TumorEGFR protein, humanErbB ReceptorsImmune Checkpoint InhibitorsEGFR exon 20 insertion mutations (Ex20ins)immune checkpoint blockade (ICB)immunotherapynon-small-cell lung cancer (NSCLC)PD-L1

Identifiers

PMID33946594
PMCPMC8147255
OpenAlexW3157623590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.