Evidence map›Paper›PMID 33946558›Full record

ReviewInternational journal of molecular sciences2021

Current and Prospective Methods for Assessing Anti-Tumor Immunity in Colorectal Cancer.

Yulia I Nussbaum, Yariswamy Manjunath, Kanve N Suvilesh, Wesley C Warren, Chi-Ren Shyu, Jussuf T Kaifi, Matthew A Ciorba, Jonathan B Mitchem

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Frontiers in immunology · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yulia I NussbaumInstitute for Data Science and Informatics, University of Missouri, Columbia, MO 65201, USA.ORCID 0000-0001-8707-3007
Yariswamy ManjunathDepartment of Surgery, Columbia, MO 65212, USA.
Kanve N SuvileshDepartment of Surgery, Columbia, MO 65212, USA.
Wesley C WarrenDepartment of Surgery, Columbia, MO 65212, USA.
Chi-Ren ShyuInstitute for Data Science and Informatics, University of Missouri, Columbia, MO 65201, USA.ORCID 0000-0001-9197-9522
Jussuf T KaifiInstitute for Data Science and Informatics, University of Missouri, Columbia, MO 65201, USA.ORCID 0000-0003-3425-2356
Matthew A CiorbaSiteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-7656-0982
Jonathan B MitchemInstitute for Data Science and Informatics, University of Missouri, Columbia, MO 65201, USA.ORCID 0000-0002-5385-7038
University of Missouri · USWashington University in St. Louis · USHarry S. Truman Memorial Veterans' Hospital · US

Funding

Washington University Institute of Clinical and Translational Sciences (KL2) KL2TR002346 · NCATS · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 2017 to 2026
$14.0M
Optimizing anti-tumor immunity for maximal therapeutic efficacy in Colorectal CancerIK2BX004346 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI MITCHEM, JONATHAN B. · 2019 to 2024
–
BLRD VA IK2 BX004346NIH HHS KL2TR002346U.S. Department of Veterans Affairs K2-BX004346-01A1
6 · The paper itself

Abstract

Colorectal cancer (CRC) remains one of the deadliest malignancies worldwide despite recent progress in treatment strategies. Though immune checkpoint inhibition has proven effective for a number of other tumors, it offers benefits in only a small group of CRC patients with high microsatellite instability. In general, heterogenous cell groups in the tumor microenvironment are considered as the major barrier for unveiling the causes of low immune response. Therefore, deconvolution of cellular components in highly heterogeneous microenvironments is crucial for understanding the immune contexture of cancer. In this review, we assimilate current knowledge and recent studies examining anti-tumor immunity in CRC. We also discuss the utilization of novel immune contexture assessment methods that have not been used in CRC research to date.

Indexed as

AnimalsColorectal NeoplasmsComputational BiologyHumansImmunityImmunologic SurveillanceImmunotherapyTumor Microenvironmentanti-tumor immunitybioinformaticscolorectal cancerimmune surveillancetumor microenvironment

Identifiers

PMID33946558
PMCPMC8125332
OpenAlexW3159298628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.