Evidence map›Paper›PMID 33946555›Full record

ArticleVaccines2021

Thermostable, Dissolvable Buccal Film Rotavirus Vaccine Is Highly Effective in Neonatal Gnotobiotic Pig Challenge Model.

Casey Hensley, Peng Zhou, Sofia Schnur, Hassan M Mahsoub, Yu Liang, Min-Xuan Wang, Caroline Page, Lijuan Yuan, Victor Bronshtein

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Casey HensleyDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.
Peng ZhouDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.
Sofia SchnurDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.
Hassan M MahsoubDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.ORCID 0000-0002-1350-7172
Yu LiangDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.
Min-Xuan WangUniversal Stabilization Technologies, Inc., San Diego, CA 92121, USA.ORCID 0000-0003-1580-678X
Caroline PageUniversal Stabilization Technologies, Inc., San Diego, CA 92121, USA.
Lijuan YuanDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.ORCID 0000-0003-0709-5228
Victor BronshteinUniversal Stabilization Technologies, Inc., San Diego, CA 92121, USA.
Virginia–Maryland College of Veterinary Medicine · USUniversal Stabilization Technologies · US

Funding

Development of a thermostable rotavirus vaccine for mucosal delivery withoutneed for reconstitution - Phase IIR44AI118009 · NIAID · UNIVERSAL STABILIZATION TECHNOLOGIES · PI BRONSHTEIN, VICTOR · 2017 to 2018
$1.3M
Development of a thermostable rotavirus vaccine for mucosal delivery without need for reconstitutionR43AI118009 · NIAID · UNIVERSAL STABILIZATION TECHNOLOGIES · PI BRONSHTEIN, VICTOR · 2015 to 2015
$148k
National Institute of Allergy and Infectious Diseases 2R44AI118009-02NIAID NIH HHS R43 AI118009NIAID NIH HHS R44 AI118009
6 · The paper itself

Abstract

Difficulties related to storage and transport of currently available live oral rotavirus vaccines can have detrimental consequences on the efficacy of the vaccines. Thus, there is a great need for thermostable vaccines that can eliminate the necessity for cold chain storage or reconstitution before administration. In this study, we developed a dissolvable oral polymeric film comprised of a live attenuated thermostable tetravalent rhesus-human reassortant rotavirus vaccine (RRV-TV) powder and antacid (CaCO

Indexed as

diarrheagnotobiotic pigsoral film vaccinerotavirusthermostable

Identifiers

PMID33946555
PMCPMC8147248
OpenAlexW3159446085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.