ArticleCancers2021
PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells.
Open access · goldAbstract read
In one paragraph
Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Mitochondrial DNA Mutations in Colorectal Cancer Stem Cells: Implications for Tumor Dynamics and Therapeutic Strategies.Current medicinal chemistry · 2026Review
- Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease.Journal of cardiovascular translational research · 2025Review
- Crosstalk between non-coding RNAs and programmed cell death in colorectal cancer: implications for targeted therapy.Epigenetics & chromatin · 2025Review
- IL-22 regulates MASTL expression in intestinal epithelial cells.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Stable Dietary Ora-Curcumin Formulation Protects from Experimental Colitis and Colorectal Cancer.Cells · 2024Article
- Integration of single-cell sequencing and bulk RNA-seq to identify and develop a prognostic signature related to colorectal cancer stem cells.Scientific reports · 2024Article
- Albendazole inhibits colon cancer progression and therapy resistance by targeting ubiquitin ligase RNF20.British journal of cancer · 2024Article
- Role of protein degradation systems in colorectal cancer.Cell death discovery · 2024Review
- Colorectal Cancer Stem Cells and Targeted Agents.Pharmaceutics · 2023Review
- Article
- P62/SQSTM1 binds with claudin-2 to target for selective autophagy in stressed intestinal epithelium.Communications biology · 2023Article
- Crosstalk between autophagy and CSCs: molecular mechanisms and translational implications.Cell death & disease · 2023Review
- Blocking the Wnt/β‑catenin signaling pathway to treat colorectal cancer: Strategies to improve current therapies (Review).International journal of oncology · 2023Review
- Re-Sensitizing Cancer Stem Cells to Conventional Chemotherapy Agents.International journal of molecular sciences · 2023Review
- The mMolecular cancer · 2022Article
- Wnt signaling in colorectal cancer: pathogenic role and therapeutic target.Molecular cancer · 2022Review
- The genomic and transcriptional landscape of primary central nervous system lymphoma.Nature communications · 2022Article
- SNORD1C maintains stemness and 5-FU resistance by activation of Wnt signaling pathway in colorectal cancer.Cell death discovery · 2022Article
- UHMK1-dependent phosphorylation of Cajal body protein coilin alters 5-FU sensitivity in colon cancer cells.Cell communication and signaling : CCS · 2022Article
- Deconvoluting the complexity of autophagy in colorectal cancer: From crucial pathways to targeted therapies.Frontiers in oncology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Balawant KumarDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198-6125, USA.
Rizwan AhmadDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198-6125, USA.
Swagat SharmaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198-6125, USA.
Saiprasad GowrikumarDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198-6125, USA.ORCID 0000-0002-9758-5425
Mark PrimeauxDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198-6125, USA.
Sandeep RanaEppley Institute for Cancer Research Program, University of Nebraska Medical Center, Omaha, NE 68198-6125, USA.ORCID 0000-0001-5802-5970
Amarnath NatarajanEppley Institute for Cancer Research Program, University of Nebraska Medical Center, Omaha, NE 68198-6125, USA.ORCID 0000-0001-5067-0203
David OupickyDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198-6125, USA.
Corey R HopkinsDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198-6125, USA.
Punita DhawanDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198-6125, USA.
Amar B SinghDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198-6125, USA.
University of Nebraska Medical Center · USNebraska Medical Center · USVA Nebraska Western Iowa Health Care System · US
Funding
Nebraska Center for Nanomedicine- Pilot ProjectsP30GM127200 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BRONICH, TATIANA K · 2018 to 2022
$5.7MChloroquine-based polymer particles as oral non-absorbable treatment of inflammatory bowel diseaseR01DK124095 · NIDDK · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI OUPICKY, DAVID, SINGH, AMAR B · 2020 to 2023
$2.1MMastl, a novel therapeutic target in Colon CancerR21CA216746 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DHAWAN, PUNITA · 2018 to 2019
$358kRole of Claudin-1 in Colon CancerI01BX002086 · VA · VETERANS HEALTH ADMINISTRATION · PI DHAWAN, PUNITA · 2013 to 2022
–Role of Claudin-2 in Colon TumorigenesisI01BX002761 · VA · OMAHA VA MEDICAL CENTER · PI SINGH, AMAR B · 2016 to 2023
–BLRD VA I01 BX002086BLRD VA I01 BX002761Foundation for the National Institutes of Health 1R01DK124095NCI NIH HHS R21 CA216746NIDDK NIH HHS R01 DK124095NIGMS NIH HHS P30 GM127200NIH HHS CA216746
Abstract
PubMed holds no abstract for this paper.
Indexed as
5-FloroUracilautophagycancer stem cellschemoresistancePI3KC3
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.