Evidence map›Paper›PMID 33946495›Full record

ArticleCancers2021

Xuanmao Jiao, Lifeng Tian, Zhao Zhang, Joanna Balcerek, Andrew V Kossenkov, Mathew C Casimiro, Chenguang Wang, Yichuan Liu, Adam Ertel, Raymond E Soccio and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Xuanmao JiaoPennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, Wynnewood, PA 19096, USA.
Lifeng TianDepartment of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Zhao ZhangPennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, Wynnewood, PA 19096, USA.
Joanna BalcerekDivision of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, USA.
Andrew V KossenkovCenter for Systems and Computational Biology, The Wistar Institute, Philadelphia, PA 19107, USA.
Mathew C CasimiroPennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, Wynnewood, PA 19096, USA.
Chenguang WangDepartment of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Yichuan LiuCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19146, USA.
Adam ErtelDepartment of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Raymond E SoccioDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Department of Genetics, and the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Eric R ChenDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Department of Genetics, and the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Qin LiuCenter for Systems and Computational Biology, The Wistar Institute, Philadelphia, PA 19107, USA.
Anthony W AshtonPennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, Wynnewood, PA 19096, USA.ORCID 0000-0001-6063-1566
Wei TongDivision of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, USA.
Richard G PestellPennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, Wynnewood, PA 19096, USA.ORCID 0000-0003-3244-8777
Baruch S. Blumberg Institute · USChildren's Hospital of Philadelphia · USThomas Jefferson University · USThe Wistar Institute · USUniversity of Pennsylvania · USAbraham Baldwin Agricultural College · USLankenau Institute for Medical Research · US

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Joseph M Salvino · 1985 to 2026
$75.9M
Lnk Regulatory Functions in Hematopoietic Stem CellsR01HL095675 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI TONG, WEI · 2009 to 2021
$5.6M
DACH1/Eya Cell fate determination factor and mammary tumorigenesisR01CA132115 · NCI · THOMAS JEFFERSON UNIVERSITY · PI PESTELL, RICHARD G · 2009 to 2018
$3.1M
Regulation of Ribosome Biogenesis in Hematopoietic Stem CellsR01DK127738 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI TONG, WEI · 2020 to 2024
$3.0M
Regulation of protein ubiquitination in hematopoietic cytokine signalingR01HL133828 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI TONG, WEI · 2017 to 2020
$2.2M
Integrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center LevelR50CA211199 · NCI · WISTAR INSTITUTE · PI Andrew V Kossenkov · 2016 to 2026
$1.6M
A novel hematopoietic stem cell populationF31CA180604 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BALCEREK, JOANNA · 2013 to 2016
$142k
NCI NIH HHS P30 CA010815NCI NIH HHS R50 CA211199NHLBI NIH HHS R01 HL095675NHLBI NIH HHS R01 HL133828NIDDK NIH HHS R01 DK127738NIH HHS F31CA180604NIH HHS R01CA132115NIH HHS R01HL095675NIH HHS R01HL133828NIH HHS R21CA235139-01U.S. Department of Defense W81XWH1810605
6 · The paper itself

Abstract

HER2, which is associated with clinically aggressive disease, is overexpressed in 15-20% of breast cancers (BC). The host immune system participates in the therapeutic response of HER2

Indexed as

breast cancerlipogenesisperoxisome proliferator-activated receptor gamma (PPARγ), nuclear receptor

Identifiers

PMID33946495
PMCPMC8125290
OpenAlexW3158402884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.