Evidence map›Paper›PMID 33946440›Full record

ArticleBiomolecules2021

Influence of Culture Substrates on Morphology and Function of Pulmonary Alveolar Cells In Vitro.

Chiara Emma Campiglio, Marina Figliuzzi, Sara Silvani, Matteo Tironi, Sara Conti, Federica Boschetti, Andrea Remuzzi

Open access · goldAbstract readComparative Study
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Juglans regiaJournal of tropical medicine · 2025
    Article
  5. Electrotaxis of alveolar epithelial cells in direct-current electric fields.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2023
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Chiara Emma CampiglioDepartment of Management, Information and Production Engineering, University of Bergamo, 24044 Dalmine (BG), Italy.ORCID 0000-0002-2800-9539
Marina FigliuzziDepartment of Biomedical Engineering, Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, 24126 Bergamo, Italy.
Sara SilvaniDepartment of Biomedical Engineering, Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, 24126 Bergamo, Italy.
Matteo TironiDepartment of Biomedical Engineering, Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, 24126 Bergamo, Italy.
Sara ContiDepartment of Molecular Medicine, Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, 24126 Bergamo, Italy.
Federica BoschettiDepartment of Chemistry, Materials and Chemical Engineering Giulio Natta, Politecnico di Milano, 20131 Milan, Italy.ORCID 0000-0002-1932-7535
Andrea RemuzziDepartment of Management, Information and Production Engineering, University of Bergamo, 24044 Dalmine (BG), Italy.ORCID 0000-0002-4301-8927
Mario Negri Institute for Pharmacological Research · ITUniversity of Bergamo · ITPolitecnico di Milano · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell's microenvironment has been shown to exert influence on cell behavior. In particular, matrix-cell interactions strongly impact cell morphology and function. The purpose of this study was to analyze the influence of different culture substrate materials on phenotype and functional properties of lung epithelial adenocarcinoma (A549) cells. A549 cells were seeded onto two different biocompatible, commercially available substrates: a polyester coverslip (Thermanox™ Coverslips), that was used as cell culture plate control, and a polydimethylsiloxane membrane (PDMS, Elastosil

Indexed as

A549 CellsAdaptor Proteins, Signal TransducingAlveolar Epithelial CellsCell Culture TechniquesCell Line, TumorCulture MediaDimethylpolysiloxanesHumansLipopeptidesLungMicroscopy, Electrochemical, ScanningPeptides, CyclicPolyestersPulmonary AlveoliTranscription FactorsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingbaysilonCulture MediaDimethylpolysiloxanesLipopeptidesPeptides, CyclicPolyesterssurfactin peptideTranscription FactorsYAP1 protein, humanYAP-Signaling Proteinscell functioncell morphologylung epithelial cellsmechanobiologysubstrate properties

Identifiers

PMID33946440
PMCPMC8147120
OpenAlexW3157119356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.