Evidence map›Paper›PMID 33946406›Full record

ArticleViruses2021

Arsenicals, the Integrated Stress Response, and Epstein-Barr Virus Lytic Gene Expression.

Jaeyeun Lee, Jennifer Stone, Prashant Desai, John G Kosowicz, Jun O Liu, Richard F Ambinder

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jaeyeun LeeDepartments of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Jennifer StoneDepartments of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Prashant DesaiDepartments of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
John G KosowiczDepartments of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Jun O LiuDepartments of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Richard F AmbinderDepartments of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
Elucidation of genetic networks of HSV-1 virion proteins and discovery of their functions in the morphogenesis of the infectious virus particleR01AI137365 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DESAI, PRASHANT J, VASHEE, SANJAY · 2019 to 2024
$3.2M
NCI NIH HHS P30CA06973NIAID NIH HHS R01 AI137365
6 · The paper itself

Abstract

Following our observation that clofoctol led to Epstein-Barr virus (EBV) lytic gene expression upon activation of the integrated stress response (ISR), we decided to investigate the impact of As

Indexed as

Stress, PhysiologicalArsenicalsBiomarkersCell Line, TumorCells, CulturedEpstein-Barr Virus InfectionsHerpesvirus 4, HumanHost-Pathogen InteractionsHumansModels, BiologicalVirus ActivationVirus ReplicationArsenicalsBiomarkersarsenicEpstein–Barr virusintegrated stress response

Identifiers

PMID33946406
PMCPMC8147158
OpenAlexW3157880348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.