ReviewChildren (Basel, Switzerland)2021
Accuracy of Pulse Oximetry in the Presence of Fetal Hemoglobin-A Systematic Review.
Review in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Skin Pigmentation Influence on Pulse Oximetry Accuracy: A Systematic Review and Bibliometric Analysis.Sensors (Basel, Switzerland) · 2022Pooled it
- Fetal Hemoglobin and Tissue Oxygenation Measured With Near-Infrared Spectroscopy-A Systematic Qualitative Review.Frontiers in pediatrics · 2021Pooled it
- Is small for gestational age associated with reduced oxygen saturation to FiOEuropean journal of pediatrics · 2026Article
- Pulse Oximeters: Accuracy and Artifacts.Advances in experimental medicine and biology · 2026Review
- Fetal haemoglobin and oxygen requirement in preterm infants: an observational study.Archives of disease in childhood. Fetal and neonatal edition · 2025Observational
- Addressing the Humans in the Delivery Room-Optimising Neonatal Monitoring and Decision-Making in Transition.Children (Basel, Switzerland) · 2025Review
- Creative music therapy in preterm infants effects cerebrovascular oxygenation and perfusion.Scientific reports · 2024Article
- Pulse oximetry in pediatric care: Balancing advantages and limitations.World journal of clinical pediatrics · 2024Article
- Machine Learning Detects Intraventricular Haemorrhage in Extremely Preterm Infants.Children (Basel, Switzerland) · 2023Article
- Stabilization and Resuscitation of Newborns.Children (Basel, Switzerland) · 2022Article
- Does Oxygen Content Play a Role in Spontaneous Closure of Perimembranous Ventricular Septal Defects?Children (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Continuous monitoring of arterial oxygen saturation by pulse oximetry (SpO2) is the main method to guide respiratory and oxygen support in neonates during postnatal stabilization and after admission to neonatal intensive care unit. The accuracy of these devices is therefore crucial. The presence of fetal hemoglobin (HbF) in neonatal blood might affect SpO2 readings. We performed a systematic qualitative review to investigate the impact of HbF on SpO2 accuracy in neonates. PubMed/Medline, Embase, Cumulative Index to Nursing & Allied Health database (CINAHL) and Cochrane library databases were searched from inception to January 2021 for human studies in the English language, which compared arterial oxygen saturations (SaO2) from neonatal blood with SpO2 readings and included HbF measurements in their reports. Ten observational studies were included. Eight studies reported SpO2-SaO2 bias that ranged from -3.6%, standard deviation (SD) 2.3%, to +4.2% (SD 2.4). However, it remains unclear to what extent this depends on HbF. Five studies showed that an increase in HbF changes the relation of partial oxygen pressure (paO2) to SpO2, which is physiologically explained by the leftward shift in oxygen dissociation curve. It is important to be aware of this shift when treating a neonate, especially for the lower SpO2 limits in preterm neonates to avoid undetected hypoxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.