Evidence map›Paper›PMID 33946042›Full record

ArticleAging2021

Predicting intraventricular hemorrhage growth with a machine learning-based, radiomics-clinical model.

Dong-Qin Zhu, Qian Chen, Yi-Lan Xiang, Chen-Yi Zhan, Ming-Yue Zhang, Chao Chen, Qi-Chuan Zhuge, Wei-Jian Chen, Xiao-Ming Yang, Yun-Jun Yang

Open access · greenAbstract readValidation Study
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Dong-Qin ZhuDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Qian ChenDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Yi-Lan XiangDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Chen-Yi ZhanDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Ming-Yue ZhangDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Chao ChenDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Qi-Chuan ZhugeDepartment of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Wei-Jian ChenDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Xiao-Ming YangDepartment of Radiology, Lab-Yang, University of Washington, Seattle, WA 98109, USA.
Yun-Jun YangDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
First Affiliated Hospital of Wenzhou Medical University · CNWenzhou Medical University · CNUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We constructed a radiomics-clinical model to predict intraventricular hemorrhage (IVH) growth after spontaneous intracerebral hematoma. The model was developed using a training cohort (N=626) and validated with an independent testing cohort (N=270). Radiomics features and clinical predictors were selected using the least absolute shrinkage and selection operator (LASSO) method and multivariate analysis. The radiomics score (Rad-score) was calculated through linear combination of selected features multiplied by their respective LASSO coefficients. The support vector machine (SVM) method was used to construct the model. IVH growth was experienced by 13.4% and 13.7% of patients in the training and testing cohorts, respectively. The Rad-score was associated with severe IVH and poor outcome. Independent predictors of IVH growth included hypercholesterolemia (odds ratio [OR], 0.12 [95%CI, 0.02-0.90]; p=0.039), baseline Graeb score (OR, 1.26 [95%CI, 1.16-1.36]; p<0.001), time to initial CT (OR, 0.70 [95%CI, 0.58-0.86]; p<0.001), international normalized ratio (OR, 4.27 [95%CI, 1.40, 13.0]; p=0.011), and Rad-score (OR, 2.3 [95%CI, 1.6-3.3]; p<0.001). In the training cohort, the model achieved an AUC of 0.78, sensitivity of 0.83, and specificity of 0.66. In the testing cohort, AUC, sensitivity, and specificity were 0.71, 0.81, and 0.64, respectively. This radiomics-clinical model thus has the potential to predict IVH growth.

Indexed as

AgedCerebral Intraventricular HemorrhageCerebral VentriclesFeasibility StudiesFemaleHumansHydrocephalusHypercholesterolemiaImage Processing, Computer-AssistedInternational Normalized RatioMaleMiddle AgedPredictive Value of TestsRetrospective StudiesRisk AssessmentRisk Factorscerebral intraventricular hemorrhagedecision support techniquesmachine learningmultidetector computed tomographyprecision medicine

Identifiers

PMID33946042
PMCPMC8148477
OpenAlexW3159132643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.