ArticleImmunity2021
Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation.
Open access · bronzeAbstract read
In one paragraph
Article in Immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 125 citations in OpenAlex.
- ASB2 inhibits lipid accumulation to promote ILC1 homeostatic fitness and anti-tumor immunity in the mouse liver.Nature communications · 2026Article
- Article
- Review
- Dysregulation of macrophage lipid metabolism underlies intracellular bacterial neuroinvasion.Nature communications · 2026Article
- Transcriptional networks weaving natural killer anti-tumor immune response.Molecular cancer · 2026Review
- STING-Dependent spontaneous platelet adhesion potentiates NK cell proinflammatory responses in pediatric crohn's disease.Blood research · 2025Article
- TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells to support murine pregnancy.bioRxiv : the preprint server for biology · 2025Article
- Tumor desialylation surpasses anti-PD-L1 checkpoint therapy in restoring anti-tumor immunity in a murine model for colorectal cancer.International journal of cancer · 2025Article
- Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regeneration.Nature immunology · 2025Article
- Low-Input Assay for Transposase-Accessible Chromatin Identifies Epigenetic Signatures of Liver Group 1 Innate Lymphoid Cells.European journal of immunology · 2025Article
- Cellular Cosmetics: How Innate Lymphoid Cells Can Recontour the Tumour Microenvironment.European journal of immunology · 2025Review
- Type I interferon regulation of group I ILC subsets during both homeostasis and cytomegalovirus infection.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Review
- GLI2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating WNT and Prostaglandin Signaling.Cancer research · 2025Article
- Role of liver-resident NK cells in liver immunity.Hepatology international · 2025Review
- Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells.The Journal of experimental medicine · 2025Article
- Unraveling NK cell heterogeneity through single-cell sequencing: insights from physiological and tumor contexts for clinical applications.Frontiers in immunology · 2025Review
- Inflammatory, Functional, and Compositional Changes of the Uterine Immune Microenvironment in a Lymphangioleiomyomatosis Mouse Model.Journal of cellular immunology · 2025Article
- Natural killer cells in skin: a unique opportunity to better characterize the many facets of an overlooked secondary lymphoid organ.Frontiers in immunology · 2025Review
- Dietary fiber promotes antigen presentation on intestinal epithelial cells and development of small intestinal CD4Mucosal immunology · 2024Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Adelle P McFarlandDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Adam YalinDepartment of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Shuang-Yin WangDepartment of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Victor S CortezDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Tomer LandsbergerDepartment of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Raki SudanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Vincent PengDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Hannah L MillerDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Biancamaria RicciDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Eyal DavidDepartment of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Roberta FaccioDepartment of Orthopedics, Washington University School of Medicine, St. Louis, MO, USA; Shriners Children's Hospital in St. Louis, St. Louis, MO, USA.
Ido AmitDepartment of Immunology, Weizmann Institute of Science, Rehovot, Israel. Electronic address: ido.amit@weizmann.ac.il.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: mcolonna@wustl.edu.
Washington University in St. Louis · USWeizmann Institute of Science · ILSt. Louis Children's Hospital · US
Funding
Pediatric Gastroenterology Research Training ProgramT32DK077653 · NIDDK · WASHINGTON UNIVERSITY · PI PHILLIP I TARR · 2007 to 2026
$5.8MCIS-REGULATORY CIRCUITS FOR ILC FUNCTION AND PLASTICITYR01AI134035 · NIAID · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Eugene M Oltz · 2018 to 2026
$4.8MThe Role of Group 3 Innate Lymphoid cells (ILC3) in TuberculosisR01AI134236 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, KHADER, SHABAANA A. · 2017 to 2021
$4.4MThe role of TGFbeta in development and function of salivary gland innate lymphoid cellsR01DE025884 · NIDCR · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, WEISMAN, GARY ANDREW · 2017 to 2021
$3.5MNovel Regulators of Inflammatory Arthritis and Bone ErosionR01AR066551 · NIAMS · WASHINGTON UNIVERSITY · PI FACCIO, ROBERTA · 2015 to 2020
$2.0MRole of Bone in Primary and Metastatic CancerR01CA235096 · NCI · WASHINGTON UNIVERSITY · PI FACCIO, ROBERTA · 2020 to 2024
$1.8MPlasticity of Innate Lymphoid Cells: Mechanisms and Biological ImpactR01DK124699 · NIDDK · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2020 to 2023
$1.4MDetermining the contribution of polyamine biosynthesis to the function of group 3 innate lymphoid cells in the gastrointestinal systemF30DK127540 · NIDDK · WASHINGTON UNIVERSITY · PI PENG, VINCENT · 2020 to 2022
$106kNCI NIH HHS R01 CA235096NIAID NIH HHS R01 AI134035NIAID NIH HHS R01 AI134236NIAMS NIH HHS R01 AR066551NIDCR NIH HHS R01 DE025884NIDDK NIH HHS F30 DK127540NIDDK NIH HHS R01 DK124699NIDDK NIH HHS T32 DK077653
Abstract
Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate lymphocytes broadly defined in mice as Lin
Indexed as
AnimalsCell Line, TumorFemaleHumansImmunity, InnateKiller Cells, NaturalLymphocytesMaleMiceMice, Inbred C57BLNatural Cytotoxicity Triggering Receptor 1NeoplasmsNK Cell Lectin-Like Receptor Subfamily BSingle-Cell AnalysisTranscription FactorsNatural Cytotoxicity Triggering Receptor 1NK Cell Lectin-Like Receptor Subfamily BTranscription FactorsEOMESglycolysisHOBITinnate lymphoid cellsnatural killer cellssingle-cell RNA sequencingTCF-1tissuetranscription factortumor
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.