ArticleAge and ageing2021
Hospitalisation without delirium is not associated with cognitive decline in a population-based sample of older people-results from a nested, longitudinal cohort study.
Article in Age and ageing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients.The Cochrane database of systematic reviews · 2021Pooled it
- Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients.The Cochrane database of systematic reviews · 2021Pooled it
- Delirium: a modifiable risk factor for dementia.European geriatric medicine · 2026Review
- Hospital-Diagnosed Infections, Autoimmune Diseases, and Subsequent Dementia Incidence.JAMA network open · 2023Article
- Assessing healthcare outcomes among patients with dementia requiring hospitalization for COVID-19: An observational study.Journal of the American Geriatrics Society · 2023Observational
- Article
- Three key areas in progressing delirium practice and knowledge: recognition and relief of distress, new directions in delirium epidemiology and developing better research assessments.Age and ageing · 2022Article
- Delirium can be safely managed in the community through implementation of a community toolkit: a proof-of-concept pilot study.Future healthcare journal · 2022Article
- Delirium in COVID-19: common, distressing and linked with poor outcomes. . . can we do better?Age and ageing · 2021Article
- Advancing dementia identification using machine learning and real-world sequential health data.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundAcute hospitalisation and delirium have individually been shown to adversely affect trajectories of cognitive decline but have not previously been considered together. This work aimed to explore the impact on cognition of hospital admission with and without delirium, compared to a control group with no hospital admissions.
methodsThe Delirium and Cognitive Impact in Dementia (DECIDE) study was nested within the Cognitive Function and Ageing Study II (CFAS II)-Newcastle cohort. CFAS II participants completed two baseline interviews, including the Mini-Mental State Examination (MMSE). During 2016, surviving participants from CFAS II-Newcastle were recruited to DECIDE on admission to hospital. Participants were reviewed daily to determine delirium status.During 2017, all DECIDE participants and age, sex and years of education matched controls without hospital admissions during 2016 were invited to repeat the CFAS II interview. Delirium was excluded in the control group using the Informant Assessment of Geriatric Delirium Scale (i-AGeD). Linear mixed effects modelling determined predictors of cognitive decline.
resultsDuring 2016, 82 of 205 (40%) DECIDE participants had at least one episode of delirium. At 1 year, 135 of 205 hospitalised participants completed an interview along with 100 controls. No controls experienced delirium (i-AGeD>4). Delirium was associated with a faster rate of cognitive decline compared to those without delirium (β = -2.2, P < 0.001), but number of hospital admissions was not (P = 0.447).
conclusionsThese results suggest that delirium during hospitalisation rather than hospitalisation per se is a risk factor for future cognitive decline, emphasising the need for dementia prevention studies that focus on delirium intervention.
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