Evidence map›Paper›PMID 33945466›Full record

ArticleeLife2021

DRAXIN regulates interhemispheric fissure remodelling to influence the extent of corpus callosum formation.

Laura Morcom, Timothy J Edwards, Eric Rider, Dorothy Jones-Davis, Jonathan Wc Lim, Kok-Siong Chen, Ryan J Dean, Jens Bunt, Yunan Ye, Ilan Gobius and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Implications of draxin in neurological disorders.Frontiers in cell and developmental biology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Laura Morcom *The University of Queensland, Queensland Brain Institute, Brisbane, Australia.ORCID 0000-0001-6683-4356
Timothy J Edwards *The University of Queensland, Queensland Brain Institute, Brisbane, Australia.ORCID 0000-0002-2175-7964
Eric RiderDepartments of Neurology and Pediatrics, Institute of Human Genetics and Weill Institute of Neurosciences, University of California, San Francisco, San Francisco, United States.ORCID 0000-0002-4019-0238
Dorothy Jones-DavisDepartments of Neurology and Pediatrics, Institute of Human Genetics and Weill Institute of Neurosciences, University of California, San Francisco, San Francisco, United States.
Jonathan Wc LimThe University of Queensland, Queensland Brain Institute, Brisbane, Australia.ORCID 0000-0002-5074-6359
Kok-Siong ChenThe University of Queensland, Queensland Brain Institute, Brisbane, Australia.ORCID 0000-0001-5796-5290
Ryan J DeanThe University of Queensland, Queensland Brain Institute, Brisbane, Australia.ORCID 0000-0002-7146-1352
Jens BuntThe University of Queensland, Queensland Brain Institute, Brisbane, Australia.ORCID 0000-0003-0397-2019
Yunan YeThe University of Queensland, Queensland Brain Institute, Brisbane, Australia.ORCID 0000-0001-9084-6314
Ilan GobiusThe University of Queensland, Queensland Brain Institute, Brisbane, Australia.ORCID 0000-0003-3255-2531
Rodrigo SuárezThe University of Queensland, Queensland Brain Institute, Brisbane, Australia.ORCID 0000-0001-5153-5652
Simone MandelstamDepartment of Radiology, University of Melbourne, Royal Children's Hospital, Parkville, Australia.
Elliott H SherrDepartments of Neurology and Pediatrics, Institute of Human Genetics and Weill Institute of Neurosciences, University of California, San Francisco, San Francisco, United States.ORCID 0000-0002-4118-5385
Linda J RichardsThe University of Queensland, Queensland Brain Institute, Brisbane, Australia.ORCID 0000-0002-7590-7390
The University of Queensland · AUUniversity of California, San Francisco · USRoyal Children's Hospital · AU

Funding

ZIDOVUDINE &LAMIVUDINE &NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFM01RR001271 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$22.7M
De novo copy number variation and gene discovery in human brain malformationsR01NS058721 · NINDS · UNIVERSITY OF CHICAGO · PI ARGILLI, EMANUELA · 2008 to 2025
$10.9M
NCRR NIH HHS M01 RR001271NINDS NIH HHS R01 NS058721
6 · The paper itself

Abstract

Corpus callosum dysgenesis (CCD) is a congenital disorder that incorporates either partial or complete absence of the largest cerebral commissure. Remodelling of the interhemispheric fissure (IHF) provides a substrate for callosal axons to cross between hemispheres, and its failure is the main cause of complete CCD. However, it is unclear whether defects in this process could give rise to the heterogeneity of expressivity and phenotypes seen in human cases of CCD. We identify incomplete IHF remodelling as the key structural correlate for the range of callosal abnormalities in inbred and outcrossed BTBR mouse strains, as well as in humans with partial CCD. We identify an eight base-pair deletion in

Indexed as

AdultAgedAgenesis of Corpus CallosumAnimalsCohort StudiesCorpus CallosumFemaleGene Expression Regulation, DevelopmentalHEK293 CellsHumansIntercellular Signaling Peptides and ProteinsMaleMiceMiddle AgedPhenotypeYoung Adultdraxin protein, mouseIntercellular Signaling Peptides and Proteinsastrogliaaxon guidancecerebral cortexcorpus callosumDraxinhumanmidlinemouseneuroscience

Identifiers

PMID33945466
PMCPMC8137145
OpenAlexW3158197243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.