Evidence map›Paper›PMID 33945036›Full record

Trial reportNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

Effects of greater occipital nerve block with local anesthetic and triamcinolone for treatment of medication overuse headache: an open-label, parallel, randomized, controlled clinical trial.

Arman Arab, Masoud Khoshbin, Elham Karimi, Ghazal Saberian, Mohammad Saadatnia, Fariborz Khorvash

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07568496 (Greater Occipital Nerve Block for Migraine With Medication Overuse Headache), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07568496 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Greater Occipital Nerve Block for Migraine With Medication Overuse Headache

TypeinterventionalSponsorMahidol UniversityRan2026 to 2028Enrolled130ConditionsMigraine Disorders, Medication Overuse Headache, Greater Occipital Nerve BlockArmsLidocaine 2% and Methylprednisolone 80 mg, Placebo
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Arman ArabDepartment of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Masoud KhoshbinAnesthesia and Critical Care Department, Shah Vali Hospital, Azad University of Medical Science, Yazd, Iran.
Elham KarimiDepartment of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Ghazal SaberianSchool of Medicine, Azad University of Medical Science, Yazd, Iran.
Mohammad SaadatniaIsfahan Neurosciences Research Center, Al Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Fariborz KhorvashIsfahan Neurosciences Research Center, Al Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran. fkhorvash@gmail.com.ORCID http://orcid.org/0000-0002-3293-8891
Isfahan University of Medical Sciences · IRIslamic Azad University, Yazd · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThere is a paucity of evidence and consensus on exactly how to carry out the detoxification process. To examine the effect of a greater occipital nerve block (GONB) in the detoxification process, we conducted an open-label, parallel, randomized, controlled clinical trial. MATERIALS AND

methodsIn order to conduct this study, 54 medication-overuse headache (MOH) patients were recruited and allocated randomly to group A (n = 27) or B (n = 27). In both groups, patients underwent detoxification processes without any acute migraine medication or analgesics. During the run-in period, all patients in both groups received the same education, managed by a neurologist and nutritionist. All patients were offered maximally 300 mL of promethazine syrup (5 mg/5 mL) to be taken 10 mg every 8 h during the first 10 days of the study. A 2-mL syringe containing 1 mL of lidocaine 2% and 1 mL of triamcinolone 40 mg/mL was prepared for each patient of group A for conducting GONB. Characteristics of headache attacks, including headache severity, frequency, and duration, were assessed at baseline and after 3 months of intervention.

resultsTwenty-six patients in group A (96.3%) and twenty-three in group B (85.2%) completed detoxification, and were thus cured of MOH (P = 0.351). The present study revealed that GONB with local anesthetic and triamcinolone significantly improved the characteristics of headache, including frequency (- 13.66 in group A and - 7.55 in group B), duration (- 7.92 in group A and - 5.88 in group B), and severity (- 3.44 in group A vs. - 1.33 in group B) in group A compared to control (all P value < 0.05).

conclusionsAlthough both detoxification programs were effective, detoxification with GONB resulted in better outcomes.

trial registrationIranian Registry of Clinical Trials (registration number; IRCT20150906023922N2).

Indexed as

Headache Disorders, SecondaryNerve BlockAnesthetics, LocalHeadacheHumansIranTreatment OutcomeTriamcinoloneAnesthetics, LocalTriamcinoloneDetoxificationGreater occipital nerve blockMedication overuse headache

Identifiers

PMID33945036
OpenAlexW3159595931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.