Evidence map›Paper›PMID 33945004›Full record

ArticleJournal of neurology2021

Cancer is associated with inferior outcome in patients with ischemic stroke.

Katharina Seystahl, Alessia Hug, Sung Ju Weber, Sandra Kapitza, Dorothee Gramatzki, Miriam Wanner, Mira Katan, Andreas R Luft, Sabine Rohrmann, Susanne Wegener and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Katharina SeystahlDepartment of Neurology, University Hospital and University of Zurich, CH-8091, Zurich, Switzerland. katharina.seystahl@usz.ch.ORCID http://orcid.org/0000-0002-4072-5669
Alessia Hug *Department of Neurology, University Hospital and University of Zurich, CH-8091, Zurich, Switzerland.
Sung Ju Weber *Department of Neurology, University Hospital and University of Zurich, CH-8091, Zurich, Switzerland.
Sandra KapitzaDepartment of Neurology, University Hospital and University of Zurich, CH-8091, Zurich, Switzerland.
Dorothee GramatzkiDepartment of Neurology, University Hospital and University of Zurich, CH-8091, Zurich, Switzerland.
Miriam WannerCancer Registry of the Canton of Zurich, Zug, Schaffhausen and Schwyz, University Hospital and University of Zurich, Zurich, Switzerland.
Mira KatanDepartment of Neurology, University Hospital and University of Zurich, CH-8091, Zurich, Switzerland.
Andreas R LuftDepartment of Neurology, University Hospital and University of Zurich, CH-8091, Zurich, Switzerland.
Sabine RohrmannCancer Registry of the Canton of Zurich, Zug, Schaffhausen and Schwyz, University Hospital and University of Zurich, Zurich, Switzerland.
Susanne WegenerDepartment of Neurology, University Hospital and University of Zurich, CH-8091, Zurich, Switzerland.
Michael WellerDepartment of Neurology, University Hospital and University of Zurich, CH-8091, Zurich, Switzerland.
University of Zurich · CH

Funding

Universität Zürich "Filling the gap" Foundation and "Walter und Gertrud Siegenthaler Foundation"
6 · The paper itself

Abstract

backgroundWhether patients with stroke and cancer exhibit specific characteristics has remained controversial.

methodsMedical records of patients with ischemic stroke in 2014 or 2015 registered in the Swiss Stroke Registry of Zurich were retrospectively analyzed and integrated with regional cancer registry data. Associations of clinical and outcome parameters with cancer diagnosed up to 5 years prior to stroke were tested.

resultsOf 753 patients with ischemic stroke, 59 patients with cancer were identified. History of venous thromboembolism (p < 0.001) was associated with cancer while age and cardiovascular risk factors were not. Higher levels of D-dimers (p = 0.001), erythrocyte sedimentation rate (p = 0.003), C-reactive protein (CRP) (p < 0.001), and lower levels of hemoglobin (p = 0.003) were associated with cancer. For platelets, pathologically low (p = 0.034) or high levels (p < 0.001) were linked to cancer. Modified Rankin scale (mRS) scores ≥ 4 on admission and at follow-up were more frequent in cancer patients (p = 0.038 and p = 0.001). Poor post-stroke survival was associated with cancer (HR 2.2, p < 0.001). Multivariable analysis identified venous thromboembolism (OR 5.1), pathologic platelet count (OR = 2.9), low hemoglobin (OR 2.5) and elevated CRP (OR 1.8) as independently associated with cancer. In multivariable Cox regression, risk for death was associated with cancer (HR 1.7), low hemoglobin (HR 2.6), mRS on admission ≥ 4 (HR 1.9), pathologic platelet count (HR 1.6), female sex (HR 1.7), and elevated CRP (HR 1.4).

conclusionsConsidering cancer as a cofactor for post-stroke outcome may impact clinical decision making.

Indexed as

Brain IschemiaIschemic StrokeNeoplasmsStrokeFemaleHumansPrognosisRetrospective StudiesRisk FactorsCancerRisk factorsSexStroke

Identifiers

PMID33945004
PMCPMC8505392
OpenAlexW3159000351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.