Evidence map›Paper›PMID 33944971›Full record

Trial reportDiabetologia2021

Acute hyperglycaemia does not have a consistent adverse effect on exercise performance in recreationally active young people with type 1 diabetes: a randomised crossover in-clinic study.

Karen M Rothacker, Sam Armstrong, Grant J Smith, Nat Benjanuvatra, Brendan Lay, Peter Adolfsson, Timothy W Jones, Paul A Fournier, Elizabeth A Davis

Erratum issuedOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Diabetologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Karen M RothackerDepartment of Endocrinology and Diabetes, Perth Children's Hospital, Nedlands, Western Australia, Australia. karen.rothacker@health.wa.gov.au.ORCID 0000-0002-1466-0187
Sam ArmstrongDepartment of Endocrinology and Diabetes, Perth Children's Hospital, Nedlands, Western Australia, Australia.ORCID 0000-0001-9989-6481
Grant J SmithThe Centre for Child Health Research, Telethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, Australia.ORCID 0000-0002-0584-1875
Nat BenjanuvatraSchool of Human Sciences, Division of Sport Science, Exercise and Health, The University of Western Australia, Crawley, Western Australia, Australia.ORCID 0000-0003-0342-3693
Brendan LaySchool of Human Sciences, Division of Sport Science, Exercise and Health, The University of Western Australia, Crawley, Western Australia, Australia.
Peter AdolfssonDepartment of Pediatrics, The Hospital of Halland, Kungsbacka, Sweden.ORCID 0000-0001-7615-9737
Timothy W JonesDepartment of Endocrinology and Diabetes, Perth Children's Hospital, Nedlands, Western Australia, Australia.ORCID 0000-0002-7989-1998
Paul A FournierSchool of Human Sciences, Division of Sport Science, Exercise and Health, The University of Western Australia, Crawley, Western Australia, Australia.ORCID 0000-0002-9963-9685
Elizabeth A DavisDepartment of Endocrinology and Diabetes, Perth Children's Hospital, Nedlands, Western Australia, Australia.ORCID 0000-0003-4244-5473
The Kids Research Institute Australia · AUThe University of Western Australia · AUHallands sjukhus Kungsbacka · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisIn individuals with type 1 diabetes, chronic hyperglycaemia impairs aerobic fitness. However, the effect of acute marked hyperglycaemia on aerobic fitness is unclear, and the impact of insulin level has not been examined. In this study, we explored if acute hyperglycaemia with higher or low insulin levels affects [Formula: see text] and other exercise performance indicators in individuals with type 1 diabetes.

methodsEligible participants were aged 14 to 30 years, with complication-free, type 1 diabetes and HbA

resultsTwelve recreationally active individuals with type 1 diabetes (8 male, mean ± SD 17.9 ± 3.9 years, HbA CONCLUSIONS/

interpretationAcute marked hyperglycaemia in the higher but not low insulin state impaired [Formula: see text] but to a small extent. Acute hyperglycaemia had an insulin-dependent effect on sprint cycling absolute power output and reaction time but with differing directionality (positive for sprint cycling and negative for reaction time) and no effect on the other indicators of exercise performance examined. We find that acute hyperglycaemia is not consistently adverse and does not impair overall exercise performance to an extent clinically relevant for recreationally active individuals with type 1 diabetes.

fundingThis research was funded by Diabetes Research Western Australia and Australasian Paediatric Endocrine Group grants.

Indexed as

Acute DiseaseAdolescentAdultBlood GlucoseCross-Over StudiesDiabetes Mellitus, Type 1DietDouble-Blind MethodExerciseFemaleGlucoseGlucose Clamp TechniqueHumansHyperglycemiaHypoglycemic AgentsInsulinBlood GlucoseGlucoseHypoglycemic AgentsInsulinLactic AcidBalanceClampExerciseHyperglycaemiaMuscle powerPerformanceReaction timeStrengthType 1 diabetes

Identifiers

PMID33944971
OpenAlexW3158760968

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.