ArticleeLife2021
Fully autonomous mouse behavioral and optogenetic experiments in home-cage.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- A Parallelized, Automated System for Higher-Throughput Spatial Navigation Testing of Rats.eNeuro · 2026Article
- The Training Village: an open platform for continuous testing of rodents in cognitive tasks.bioRxiv : the preprint server for biology · 2026Article
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- A Parallelized, Automated System for Higher-Throughput Spatial Navigation Testing of Rats.bioRxiv : the preprint server for biology · 2025Article
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- The barn owl in systems and behavioral neuroscience: Progress and promise.Current opinion in neurobiology · 2025Review
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- Automated head-fixation training system with high levels of animal participation in psychoacoustic tasks.PloS one · 2025Article
- Magnetic voluntary head-fixation in transgenic rats enables lifespan imaging of hippocampal neurons.Nature communications · 2024Article
- FABEL: Forecasting Animal Behavioral Events with Deep Learning-Based Computer Vision.bioRxiv : the preprint server for biology · 2024Article
- Superior colliculus bidirectionally modulates choice activity in frontal cortex.Nature communications · 2023Article
- Advances in cellular resolution microscopy for brain imaging in rats.Neurophotonics · 2023Review
- Behavioral measurements of motor readiness in mice.Current biology : CB · 2023Article
- Article
- Superior colliculus cell types bidirectionally modulate choice activity in frontal cortex.bioRxiv : the preprint server for biology · 2023Article
- Behavioral measurements of motor readiness in mice.bioRxiv : the preprint server for biology · 2023Article
- Functional Organisation of the Mouse Superior Colliculus.Frontiers in neural circuits · 2022Review
- MesoNet allows automated scaling and segmentation of mouse mesoscale cortical maps using machine learning.Nature communications · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Goal-directed behaviors involve distributed brain networks. The small size of the mouse brain makes it amenable to manipulations of neural activity dispersed across brain areas, but existing optogenetic methods serially test a few brain regions at a time, which slows comprehensive mapping of distributed networks. Laborious operant conditioning training required for most experimental paradigms exacerbates this bottleneck. We present an autonomous workflow to survey the involvement of brain regions at scale during operant behaviors in mice. Naive mice living in a home-cage system learned voluntary head-fixation (>1 hr/day) and performed difficult decision-making tasks, including contingency reversals, for 2 months without human supervision. We incorporated an optogenetic approach to manipulate activity in deep brain regions through intact skull during home-cage behavior. To demonstrate the utility of this approach, we tested dozens of mice in parallel unsupervised optogenetic experiments, revealing multiple regions in cortex, striatum, and superior colliculus involved in tactile decision-making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.