Evidence map›Paper›PMID 33942780›Full record

Observational studyMedical gas research

Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study.

Shin-Ichi Hirano, Yukimasa Aoki, Xiao-Kang Li, Naotsugu Ichimaru, Shiro Takahara, Yoshiyasu Takefuji

Open access · hybridAbstract readObservational Study
In one paragraph

Observational study in Medical gas research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. A Systematic Review of Molecular Hydrogen Therapy in Cancer Management.Asian Pacific journal of cancer prevention : APJCP · 2023
    Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Research progress in clinical utilization of HFrontiers in pharmacology · 2026
    Review
  8. Review
  9. Molecular Hydrogen in the Treatment of Respiratory Diseases.International journal of molecular sciences · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Prospects of molecular hydrogen in cancer prevention and treatment.Journal of cancer research and clinical oncology · 2024
    Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Medical gas research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Shin-Ichi HiranoMiZ Company Limited, Kamakura, Japan.
Yukimasa AokiClinic C4, Tokyo, Japan.
Xiao-Kang LiDivision of Transplantation Immunology, National Institute for Child Health and Development, Tokyo, Japan.
Naotsugu IchimaruDepartment of Advanced Technology for Transplantation, Osaka University Graduate School of Medicine, Osaka, Japan.
Shiro TakaharaDepartment of Renal Transplantation Center, Kansai Medical Hospital, Osaka, Japan.
Yoshiyasu TakefujiFaculty of Environment and Information Studies, Keio University, Fujisawa, Japan.
Kansai Medical University · JPKeio University Shonan Fujisawa · JPNational Center For Child Health and Development · JPOsaka University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although intensity-modulated radiation therapy (IMRT) has been developed as an alternative to conventional radiotherapy, reducing bone marrow damage is limited. Thus, a novel technology is needed to further mitigate IMRT-induced bone marrow damage. Molecular hydrogen (H

Indexed as

Bone MarrowUterine Cervical NeoplasmsAdultAgedAged, 80 and overFemaleHumansHydrogenMaleMiddle AgedRadiotherapy DosageRadiotherapy Planning, Computer-AssistedHydrogenbone marrow damagecancer patienthydrogen gasIMRTintensity-modulated radiation therapyplateletradiation-induced damageretrospective observational studywhite blood cell

Identifiers

PMID33942780
PMCPMC8174412
OpenAlexW3115477054

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.