Evidence map›Paper›PMID 33942374›Full record

ArticleJournal of clinical laboratory analysis2021

A nonsynonymous polymorphism (rs117179004, T392M) of hyaluronidase 1 (HYAL1) is associated with increased risk of idiopathic pulmonary fibrosis in Southern Han Chinese.

Juan Liu, Yanhan Deng, Zheng Wang, Biwen Mo, Jianghong Wei, Zhenshun Cheng, Qingzhen Peng, Guang Wei, Jingping Li, Ying Shu and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Common single nucleotide polymorphisms associated with idiopathic pulmonary fibrosis: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2024
    Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 13 institutions in 1 country.

Juan LiuKey Laboratory of Pulmonary Diseases of Health Ministry, Key Cite of National Clinical Research Center for Respiratory Disease, Department of Respiratory and Critical Care Medicine, Wuhan Clinical Medical Research Center for Chronic Airway Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.ORCID https://orcid.org/0000-0003-2048-9512
Yanhan DengDepartments of Rheumatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zheng WangDepartment of Respiratory Medicine, Henan Provincial People's Hospital & The People's Hospital of Zhengzhou University, Zhengzhou, China.
Biwen MoDepartment of Respiratory Medicine, Affiliated Hospital of Guilin Medical University, Guilin, China.
Jianghong WeiDepartment of Respiratory Medicine, Affiliated Hospital of Guilin Medical University, Guilin, China.
Zhenshun ChengDepartment of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Qingzhen PengDepartment of Respiratory Medicine, Xiaogan Central Hospital, Xiaogan, China.
Guang WeiDepartment of Respiratory Medicine, Xiaogan Central Hospital, Xiaogan, China.
Jingping LiDepartment of Respiratory Medicine, Qianjiang Central Hospital, Qianjiang, China.
Ying ShuDepartment of Respiratory Medicine, Qianjiang Central Hospital, Qianjiang, China.
Hua YangDepartment of Respiratory Medicine, University Hospital of Hubei University for Nationalities, Enshi, China.
Shirong FangDepartment of Respiratory Medicine, University Hospital of Hubei University for Nationalities, Enshi, China.
Guangwei LuoDepartment of Respiratory Medicine, Wuhan No. 1 Hospital, Wuhan, China.
Shuo YangDepartment of Respiratory Medicine, Wuhan No. 1 Hospital, Wuhan, China.
Yingnan WangDepartment of Respiratory and Critical Care Medicine, Renmin Hospital of Three Gorges University, Yichang, China.
Jing ZhuDepartment of Respiratory and Critical Care Medicine, Renmin Hospital of Three Gorges University, Yichang, China.
Jingping YangDepartment of Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Inner Mongolia Medical University, Baotou, China.
Ming WuDepartment of Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Inner Mongolia Medical University, Baotou, China.
Xuyan XuDepartment of Respiratory Medicine, Xianning Center Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, China.
Renying GeDepartment of Respiratory Medicine, Xianning Center Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, China.
Xiaoju ZhangDepartment of Respiratory Medicine, Henan Provincial People's Hospital & The People's Hospital of Zhengzhou University, Zhengzhou, China.
Weining XiongKey Laboratory of Pulmonary Diseases of Health Ministry, Key Cite of National Clinical Research Center for Respiratory Disease, Department of Respiratory and Critical Care Medicine, Wuhan Clinical Medical Research Center for Chronic Airway Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.
Xiaomei WangDepartment of Geriatrics, The First Affiliated Hospital of Army Medical University, Chongqing, China.
Zongzhe LiDepartment of Internal Medicine and Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.
Tongji Hospital · CNChina Three Gorges University · CNGuilin Medical University · CNHubei University for Nationalities · CNQianjiang Central Hospital · CNThe Central Hospital of Xiao gan · CNThird Affiliated Hospital of Inner Mongolia Medical College · CNWuhan No.1 Hospital · CNXianning Central Hospital · CNZhengzhou University · CNArmy Medical University · CNShanghai Jiao Tong University · CNWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIdiopathic pulmonary fibrosis (IPF) is a genetic heterogeneous disease with high mortality and poor prognosis. Hyaluronidase 1 (HYAL1) was found to be upregulated in fibroblasts from IPF patients, and overexpression of HYAL1 could prevent human fetal lung fibroblast proliferation. However, the genetic correlation between the HYAL1 and IPF or connective tissue diseases related interstitial lung disease (CTD-ILD) has not been determined.

methodsA two-stage study was conducted in Southern Han Chinese population. We sequenced the coding regions and flanking regulatory regions of HYAL1 in stage one (253 IPF cases and 125 controls). A statistically significant variant was further genotyped in stage two (162 IPF cases, 182 CTD-ILD cases, and 225 controls).

resultsWe identified a nonsynonymous polymorphism (rs117179004, T392M) significantly associated with increased IPF risk (dominant model: OR = 2.239, 95% CI = 1.212-4.137, p = 0.010 in stage one; OR = 2.383, 95% CI = 1.376-4.128, p = 0.002 in stage two). However, we did not observe this association in CTD-ILD (OR = 1.401, 95% CI = 0.790-2.485, p = 0.248).

conclusionOur findings suggest that the nonsynonymous polymorphism (rs117179004, T392M) may confer susceptibility to IPF in Southern Han Chinese, but is not associated with susceptibility to CTD-ILD.

Indexed as

Polymorphism, Single NucleotideAgedAsian PeopleCase-Control StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseHumansHyaluronoglucosaminidaseIdiopathic Pulmonary FibrosisLung Diseases, InterstitialMaleMiddle AgedHYAL1 protein, humanHyaluronoglucosaminidaseChinesehyaluronidase 1idiopathic pulmonary fibrosispolymorphism

Identifiers

PMID33942374
PMCPMC8183947
OpenAlexW3158830075

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.