ArticleThe Journal of physiology2021
Rapid volume pulsation of the extracellular space coincides with epileptiform activity in mice and depends on the NBCe1 transporter.
Article in The Journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- The Role of Aquaporins in Epileptogenesis-A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain.Epilepsia · 2026Article
- Tissue Oxygenation Dynamics During Seizure to Spreading Depolarization in Rat Brain.bioRxiv : the preprint server for biology · 2025Article
- Astrocytes Lingering at a Crossroads: Neuroprotection and Neurodegeneration in Neurocognitive Dysfunction.International journal of biological sciences · 2025Review
- Article
- Enhancing glymphatic fluid transport by pan-adrenergic inhibition suppresses epileptogenesis in male mice.Nature communications · 2024Article
- Astrocyte-neuron circuits in epilepsy.Neurobiology of disease · 2023Review
- Cerebrospinal Fluid Flow.Annual review of fluid mechanics · 2023Article
- Relationship between chronic hypoxia and seizure susceptibility.CNS neuroscience & therapeutics · 2022Review
- Transport in the Brain Extracellular Space: Diffusion, but Which Kind?International journal of molecular sciences · 2022Review
- Cellular mechanisms mediating activity-dependent extracellular space shrinkage in the retina.Glia · 2022Article
- The glymphatic system: Current understanding and modeling.iScience · 2022Review
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
key pointsExtracellular space (ECS) rapid volume pulsation (RVP) accompanying epileptiform activity is described for the first time. Such RVP occurs robustly in several in vitro and in vivo mouse models of epileptiform activity. In the in vitro 4-aminopyridine model of epileptiform activity, RVP depends on the activity of the electrogenic Na
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.