Evidence map›Paper›PMID 33942217›Full record

ArticleStem cell reviews and reports2022

Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing Through MiR-17-5p-mediated Enhancement of Angiogenesis.

Qian Wei, Yaxi Wang, Kui Ma, Qiankun Li, Bingmin Li, Wenzhi Hu, Xiaobing Fu, Cuiping Zhang

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In one paragraph

Article in Stem cell reviews and reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.

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  20. Topical Application of miR-200b-3p by Poloxamer 407-Based Hydrogel Accelerates Diabetic Wound Healing.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qian WeiResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center of Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, China.
Yaxi WangResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center of Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, China.
Kui MaResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center of Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, China.
Qiankun LiResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center of Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, China.
Bingmin LiResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center of Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, China.
Wenzhi HuResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center of Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, China.
Xiaobing FuResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center of Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, China. fuxiaobing@vip.sina.com.
Cuiping ZhangResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center of Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, China. zcp666666@sohu.com.ORCID 0000-0002-7713-3229
Chinese PLA General Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelial dysfunction caused by persistent hyperglycemia in diabetes is responsible for impaired angiogenesis in diabetic wounds. Extracellular vehicles (EVs) are considered potential therapeutic tools to promote diabetic wound healing. The aim of this study was to investigate the effects of EVs secreted by human umbilical cord mesenchymal stem cells (hucMSC-EVs) on angiogenesis under high glucose (HG) conditions in vivo and in vitro and to explore the underlying mechanisms. In vivo, local application of hucMSC-EVs enhanced wound healing and angiogenesis. In vitro, hucMSC-EVs promoted proliferation, migration, and tube formation by inhibiting phosphatase and tensin homolog (PTEN) expression and activating the AKT/HIF-1α/VEGF pathways. MiR-17-5p was found to be highly enriched in hucMSC-EVs. In vitro, MiR-17-5p agomirs downregulated the expression of PTEN and activated the AKT/HIF-1α/VEGF pathway to promote proliferation, migration, and tube formation in HG-treated HUVECs. In vivo, miR-17-5p agomirs mimicked the effects of hucMSC-EVs on wound healing and angiogenesis, whereas miR-17-5p inhibitors reversed their effects. Our findings suggest that hucMSC-EVs have regenerative and protective effects on HG-induced endothelial cells via transfer of miR-17-5p targeting PTEN/ AKT/HIF-1α/VEGF pathway, thereby accelerating diabetic wound healing. Thus, hucMSC-EVs may be promising therapeutic candidates for improving diabetic wound angiogenesis.

Indexed as

Diabetes MellitusExtracellular VesiclesMesenchymal Stem CellsMicroRNAsEndothelial CellsHumansNeovascularization, PathologicProto-Oncogene Proteins c-aktUmbilical CordVascular Endothelial Growth Factor AWound HealingMicroRNAsMIRN17 microRNA, humanProto-Oncogene Proteins c-aktVascular Endothelial Growth Factor AAngiogenesisDiabetic woundsExtracellular vesiclesMesenchymal stem cellsmiR-17-5p/PTEN/AKT/HIF-1α/VEGF pathway

Identifiers

PMID33942217
OpenAlexW3159539381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.