Evidence map›Paper›PMID 33942150›Full record

ArticleCancer chemotherapy and pharmacology2021

NCTR

Yan Wang, Qiong Lei, Cangjie Shen, Nan Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Cancer chemotherapy and pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Yan WangBeijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1st, Xiannongtan Street, Xicheng District, Beijing, 100050, People's Republic of China.
Qiong LeiBeijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1st, Xiannongtan Street, Xicheng District, Beijing, 100050, People's Republic of China.
Cangjie ShenBeijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1st, Xiannongtan Street, Xicheng District, Beijing, 100050, People's Republic of China.
Nan WangBeijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1st, Xiannongtan Street, Xicheng District, Beijing, 100050, People's Republic of China. wangnan@imm.ac.cn.ORCID 0000-0003-4600-101X
Chinese Academy of Medical Sciences & Peking Union Medical College · CNOpen University of China · CNUniversity of Nottingham Ningbo China · CN

Funding

Major Project of Drug Innovation 2013HXW-20, 2018ZX09711001-003-001Natural Science Foundation of Beijing Municipality 7162134
6 · The paper itself

Abstract

purposeTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) binds to death receptor (DR) 4 and DR5 and induces tumor-selective apoptosis. The fusion proteins NCTR

methodsNCTR

resultsNCTR

conclusionsNCTR

Indexed as

AnimalsApoptosisCell LineCell Line, TumorFemaleHEK293 CellsHeLa CellsHumansMCF-7 CellsMiceMice, Inbred BALB CMice, NudePolymersRecombinant Fusion ProteinsSignal TransductionTNF-Related Apoptosis-Inducing LigandPolymersRecombinant Fusion ProteinsTNF-Related Apoptosis-Inducing LigandTNFSF10 protein, humanDeath receptorsEfficacyPolymerPotencyTRAIL

Identifiers

PMID33942150
OpenAlexW3159399756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.