Evidence map›Paper›PMID 33941932›Full record

ArticleNature biotechnology2021

Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson's disease.

Ro'ee Gilron, Simon Little, Randy Perrone, Robert Wilt, Coralie de Hemptinne, Maria S Yaroshinsky, Caroline A Racine, Sarah S Wang, Jill L Ostrem, Paul S Larson and 10 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05763732 (Effects of Rhythmic Auditory Stimulation), which is not on this map. Cited by 186 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05763732 narecruitingnot on this mapstarted 2023, after this paper: background citation

Effects of Rhythmic Auditory Stimulation (RAS) on Gait in Parkinson Disease (PD) Patients With DBS

TypeinterventionalSponsorJohns Hopkins UniversityRan2023 to 2028Enrolled10ConditionsParkinson DiseaseArmsRhythmic Auditory Stimulation (RAS)
3 · Its place in the literature

Who cites it

186 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. The Place of Adaptive Deep Brain Stimulation in Parkinson's Disease: Spatial before Temporal Optimization.Movement disorders : official journal of the Movement Disorder Society · 2026
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126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ro'ee GilronDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA. roee.gilron@ucsf.edu.ORCID http://orcid.org/0000-0001-8761-5654
Simon LittleDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Randy PerroneDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Robert WiltDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Coralie de HemptinneDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Maria S YaroshinskyDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Caroline A RacineDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Sarah S WangDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Jill L OstremDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Paul S LarsonDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Doris D WangDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6112-3002
Nick B GalifianakisDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Ian O BledsoeDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Marta San LucianoDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Heather E DawesDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Gregory A WorrellMayo Systems Electrophysiology Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-2916-0553
Vaclav KremenMayo Systems Electrophysiology Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-9844-7617
David A BortonSchool of Engineering and Carney Institute, Brown University, Providence, RI, USA.ORCID http://orcid.org/0000-0003-0710-3005
Timothy DenisonDepartment of Engineering Science, University of Oxford and MRC Brain Network Dynamics Unit, Oxford, UK.
Philip A StarrDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-2733-4003

Funding

Accelerating Dissemination of Implantable Neurotechnology for Clinical ResearchU24NS113637 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BORTON, DAVID ALLENSON, DENISON, TIMOTHY · 2020 to 2024
$4.4M
Closed Loop Deep Brain Stimulation for Parkinson's DiseaseUH3NS100544 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STARR, PHILIP ANDREW · 2016 to 2022
$4.1M
Cerebellar deep brain stimulation for severe combined movement disorders and spasticity in children and young adults with cerebral palsyUH3NS128297 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Marta San Luciano · 2024 to 2026
$3.1M
Optimizing Phenogenotypic and Neuromodulation Predictors in Deep BrainStimulation Surgery for Isolated DystoniaK23NS099441 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAN LUCIANO, MARTA · 2017 to 2021
$1000k
The Role of M1 Leg Area in Volitional and Stereotyped Control of the Lower LimbI01RX002835 · VA · PROVIDENCE VA MEDICAL CENTER · PI BORTON, DAVID ALLENSON · 2019 to 2025
–
NINDS NIH HHS K23 NS099441NINDS NIH HHS U24 NS113637NINDS NIH HHS UH3 NS100544NINDS NIH HHS UH3 NS128297RRD VA I01 RX002835
6 · The paper itself

Abstract

Neural recordings using invasive devices in humans can elucidate the circuits underlying brain disorders, but have so far been limited to short recordings from externalized brain leads in a hospital setting or from implanted sensing devices that provide only intermittent, brief streaming of time series data. Here, we report the use of an implantable two-way neural interface for wireless, multichannel streaming of field potentials in five individuals with Parkinson's disease (PD) for up to 15 months after implantation. Bilateral four-channel motor cortex and basal ganglia field potentials streamed at home for over 2,600 h were paired with behavioral data from wearable monitors for the neural decoding of states of inadequate or excessive movement. We validated individual-specific neurophysiological biomarkers during normal daily activities and used those patterns for adaptive deep brain stimulation (DBS). This technological approach may be widely applicable to brain disorders treatable by invasive neuromodulation.

Indexed as

Adaptation, PhysiologicalWireless TechnologyAdultDeep Brain StimulationFemaleHumansMaleMiddle AgedMotor CortexMovementNeurophysiological MonitoringParkinson DiseaseWearable Electronic Devices

Identifiers

PMID33941932
PMCPMC8434942

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.