ArticleNature plants2021
Enhancing photosynthesis at high light levels by adaptive laboratory evolution.
Article in Nature plants, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- CurT dosage quantitatively affects thylakoid structure and PSII performance in Synechocystis sp. PCC 6803.The Plant journal : for cell and molecular biology · 2026Article
- Adaptive Laboratory Evolution inMicroorganisms · 2026Review
- Photosystem I-independent oxygenic photosynthesis in cyanobacteria.Nature communications · 2026Article
- Improving tolerance to fluctuating light through adaptive laboratory evolution in the cyanobacterium Synechocystis.Nature communications · 2026Article
- Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery.Natural product reports · 2026Review
- Photonic-chemostat engineering for efficient continuous cultivation of cyanobacteria.RSC advances · 2026Article
- Different efficiency of Orange Carotenoid Protein (OCP)-related quenching during high light regulation of two cyanobacterial species.Photosynthesis research · 2026Article
- Impact of SliP4 deletion on the high-light acclimation inmicroLife · 2026Article
- CurT/CURT1 proteins are involved in cell and chloroplast division coordination of cyanobacteria and green algae.Nature communications · 2025Article
- Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cyanobacterial redox carriers support photosynthesis in a purple phototrophic bacterium.The Biochemical journal · 2025Article
- Enhancing photosynthesis under salt stress via directed evolution in cyanobacteria.Plant physiology · 2025Article
- Biotechnological Applications of Cyanobacteria: Synechocystis and Synechococcus Strains.Advances in biochemical engineering/biotechnology · 2025Review
- Shedding light on blue-green photosynthesis: A wavelength-dependent mathematical model of photosynthesis in Synechocystis sp. PCC 6803.PLoS computational biology · 2024Article
- Polyextremophile engineering: a review of organisms that push the limits of life.Frontiers in microbiology · 2024Review
- Dynamic Changes in the Thylakoid Proteome of Cyanobacteria during Light-Regulated Thylakoid Membrane Development.Plants (Basel, Switzerland) · 2023Article
- Light and carbon: Synthetic biology toward new cyanobacteria-based living biomaterials.Materials today. Bio · 2023Article
- Engineered hypermutation adapts cyanobacterial photosynthesis to combined high light and high temperature stress.Nature communications · 2023Article
- Absolute quantification of cellular levels of photosynthesis-related proteins in Synechocystis sp. PCC 6803.Photosynthesis research · 2023Article
- Asymmetric survival in single-cell lineages of cyanobacteria in response to photodamage.Photosynthesis research · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Photosynthesis is readily impaired by high light (HL) levels. Photosynthetic organisms have therefore evolved various mechanisms to cope with the problem. Here, we have dramatically enhanced the light tolerance of the cyanobacterium Synechocystis by adaptive laboratory evolution (ALE). By combining repeated mutagenesis and exposure to increasing light intensities, we generated strains that grow under extremely HL intensities. HL tolerance was associated with more than 100 mutations in proteins involved in various cellular functions, including gene expression, photosynthesis and metabolism. Co-evolved mutations were grouped into five haplotypes, and putative epistatic interactions were identified. Two representative mutations, introduced into non-adapted cells, each confer enhanced HL tolerance, but they affect photosynthesis and respiration in different ways. Mutations identified by ALE that allow photosynthetic microorganisms to cope with altered light conditions could be employed in assisted evolution approaches and could strengthen the robustness of photosynthesis in crop plants.
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