ArticleNature plants2021
A spatiotemporal molecular switch governs plant asymmetric cell division.
Article in Nature plants, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- A suite of fluorescent timers for visualizing protein spatiotemporal dynamics in plants.Science advances · 2026Article
- Stomatal XVE: an inducible system for cell-stage-specific gene expression and editing in the stomatal lineage.The New phytologist · 2026Article
- Molecular regulation of asymmetric cell division in dicots: insights from Arabidopsis development.Molecular biology reports · 2025Review
- Mitotic entry is controlled by the plant-specific phosphatase BSL1 and cyclin-dependent kinase B.Nature plants · 2025Article
- Split-YFP-coupled interaction-dependent TurboID identifies new functions of basal cell polarity inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Guardians of Water and Gas Exchange: Adaptive Dynamics of Stomatal Development and Patterning.Plants (Basel, Switzerland) · 2025Review
- Decoding PHR-Orchestrated Stress Adaptation: A Genome-Wide Integrative Analysis of Transcriptional Regulation Under Abiotic Stress inInternational journal of molecular sciences · 2025Article
- Multi-scale dynamics influence the division potential of stomatal lineage ground cells in Arabidopsis.Nature communications · 2025Article
- The polar code for patterning: how polarity and the cytoskeleton orchestrate asymmetric cell division during plant development.Frontiers in cell and developmental biology · 2025Review
- ggPlantmap: an open-source R package for the creation of informative and quantitative ggplot maps derived from plant images.Journal of experimental botany · 2024Article
- Regulation of stomatal development by epidermal, subepidermal and long-distance signals.Plant molecular biology · 2024Review
- Cell type-specific attenuation of brassinosteroid signaling precedes stomatal asymmetric cell division.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Asymmetric cell division in plant development.Journal of integrative plant biology · 2023Review
- Article
- Protein polarization: Spatiotemporal precisions in cell division and differentiation.Current opinion in plant biology · 2022Review
- Division site determination during asymmetric cell division in plants.The Plant cell · 2022Review
- Dichotomy of the BSL phosphatase signaling spatially regulates MAPK components in stomatal fate determination.Nature communications · 2022Article
- Cell biology of the leaf epidermis: Fate specification, morphogenesis, and coordination.The Plant cell · 2022Review
- Cycling in a crowd: Coordination of plant cell division, growth, and cell fate.The Plant cell · 2022Review
- Connected function of PRAF/RLD and GNOM in membrane trafficking controls intrinsic cell polarity in plants.Nature communications · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Asymmetric cell division (ACD) requires protein polarization in the mother cell to produce daughter cells with distinct identities (cell-fate asymmetry). Here, we define a previously undocumented mechanism for establishing cell-fate asymmetry in Arabidopsis stomatal stem cells. In particular, we show that polarization of the protein phosphatase BSL1 promotes stomatal ACD by establishing kinase-based signalling asymmetry in the two daughter cells. BSL1 polarization in the stomatal ACD mother cell is triggered at the onset of mitosis. Polarized BSL1 is inherited by the differentiating daughter cell, where it suppresses cell division and promotes cell-fate determination. Plants lacking BSL proteins exhibit stomatal overproliferation, which demonstrates that the BSL family plays an essential role in stomatal development. Our findings establish that BSL1 polarization provides a spatiotemporal molecular switch that enables cell-fate asymmetry in stomatal ACD daughter cells. We propose that BSL1 polarization is triggered by an ACD checkpoint in the mother cell that monitors the establishment of division-plane asymmetry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.