ArticleNature microbiology2021
A cell surface-exposed protein complex with an essential virulence function in Ustilago maydis.
Article in Nature microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 71 citations in OpenAlex.
- A co-evolved peptide-GPCR system senses host entry to drive fungal infection.Nature communications · 2026Article
- Combinatorial cis-regulatory elements shape temporal effector expression in Ustilago maydis.Molecular plant pathology · 2026Article
- A low-cost "plant-scanner" platform for automated detection of Ustilago maydis infection in maize using deep learning.Scientific reports · 2026Article
- Aphid effector pair Mp1-Mp58 forms an effector complex that targets a host trafficking protein.Journal of experimental botany · 2026Article
- Induction of Ustilago maydis Appressorium and Filamentation.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Proteomic Strategies on the Management of Phytopathogenic Fungi.Journal of fungi (Basel, Switzerland) · 2025Review
- Live cell imaging of plant infection provides new insight into the biology of pathogenesis by the rice blast fungus Magnaporthe oryzae.Journal of microscopy · 2025Review
- Uncovering the transcriptional landscape of Fomes fomentarius during fungal-based material production through gene co-expression network analysis.Fungal biology and biotechnology · 2025Article
- Fungal impacts on Earth's ecosystems.Nature · 2025Review
- Advances in the molecular mechanism of grapevine resistance to fungal diseases.Molecular horticulture · 2025Review
- Fungal effectors: past, present, and future.Current opinion in microbiology · 2024Review
- Snowball: a novel gene family required for developmental patterning of fruiting bodies of mushroom-forming fungi (Agaricomycetes).mSystems · 2024Article
- Extracellular RNAs released by plant-associated fungi: from fundamental mechanisms to biotechnological applications.Applied microbiology and biotechnology · 2023Review
- Global Gene Expression of Post-Senescent Telomerase-NegativeJournal of fungi (Basel, Switzerland) · 2023Article
- Uptake of oomycete RXLR effectors into host cells by clathrin-mediated endocytosis.The Plant cell · 2023Article
- Clathrin-mediated endocytosis facilitates the internalization of Magnaporthe oryzae effectors into rice cells.The Plant cell · 2023Article
- Knock, knock, who is there? Two studies provide new insights into the translocation of pathogen effectors into plant cells.The Plant cell · 2023Article
- Extracellular vesicles: cross-organismal RNA trafficking in plants, microbes, and mammalian cells.Extracellular vesicles and circulating nucleic acids · 2023Article
- Review
- Roles of RNA silencing in viral and non-viral plant immunity and in the crosstalk between disease resistance systems.Nature reviews. Molecular cell biology · 2022Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant pathogenic fungi colonizing living plant tissue secrete a cocktail of effector proteins to suppress plant immunity and reprogramme host cells. Although many of these effectors function inside host cells, delivery systems used by pathogenic bacteria to translocate effectors into host cells have not been detected in fungi. Here, we show that five unrelated effectors and two membrane proteins from Ustilago maydis, a biotrophic fungus causing smut disease in corn, form a stable protein complex. All seven genes appear co-regulated and are only expressed during colonization. Single mutants arrest in the epidermal layer, fail to suppress host defence responses and fail to induce non-host resistance, two reactions that likely depend on translocated effectors. The complex is anchored in the fungal membrane, protrudes into host cells and likely contacts channel-forming plant plasma membrane proteins. Constitutive expression of all seven complex members resulted in a surface-exposed form in cultured U. maydis cells. As orthologues of the complex-forming proteins are conserved in smut fungi, the complex may become an interesting fungicide target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.