ArticleInternational journal of obesity (2005)2021
Extensive weight loss reduces glycan age by altering IgG N-glycosylation.
Article in International journal of obesity (2005), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 59 citations in OpenAlex.
- IgG Glycosylation Patterns May Identify Distinct Clinical Trajectories in Fibromyalgia Patients: A Longitudinal Pilot Study.European journal of pain (London, England) · 2026Article
- Physical activity and IgG N-glycosylation in medical students: a cross-sectional study.Croatian medical journal · 2026Article
- Multi-factorial regulatory networks of placental antibody transfer by Fc receptors and maternal IgG Fc characteristics are modulated by clinical covariate profiles.bioRxiv : the preprint server for biology · 2026Article
- Immunoglobulin G and plasma glycome in early rheumatoid arthritis differ from matched controls and link less fat-free mass to an accelerated aging phenotype: an exploratory study.Arthritis research & therapy · 2026Article
- Immune Ageing Clocks: A Methods-Oriented Review of Tasks, Modalities, Models, and Recalibration.Cells · 2026Review
- Multi-Omics Analysis of Morbid Obesity Using a Patented Unsupervised Machine Learning Platform: Genomic, Biochemical, and Glycan Insights.International journal of molecular sciences · 2026Article
- Immunoglobulin G in aging and cancer.Frontiers in immunology · 2026Review
- Immune and metabolic remodeling following bariatric surgery: Implications for targeted immunotherapy (Review).International journal of molecular medicine · 2026Review
- The Emerging Role of Sialic Acids in Obesity and Diabetes: Molecular Mechanisms and Therapeutic Perspectives.Biomolecules · 2025Review
- Immunoglobulin G N-glycosylation predicts long-term risk of ischemic stroke: a nested case-control study.Journal of translational medicine · 2025Article
- Establishment of reference intervals for serum immunoglobulin GThe EPMA journal · 2025Article
- Parallel and convergent evolution in genes underlying seasonal migration.Evolution letters · 2025Article
- Plasma N-Glycoproteomics in monozygotic twin pairs discordant for body mass index reveals an obesity signature related to inflammation and iron metabolism.Biology direct · 2025Article
- Potential Glycobiomarkers in Maternal Obesity and Gestational Diabetes During Human Pregnancy.Journal of clinical medicine · 2025Article
- The role of autoantibodies in bridging obesity, aging, and immunosenescence.Immunity & ageing : I & A · 2024Review
- Regulators of placental antibody transfer through a modeling lens.Nature immunology · 2024Review
- Clinical glycoproteomics: methods and diseases.MedComm · 2024Review
- Glycosylation in aging and neurodegenerative diseases.Acta biochimica et biophysica Sinica · 2024Review
- Untargeted metabolomics reveal signatures of a healthy lifestyle.Scientific reports · 2024Article
- Uncovering Forensic Evidence: A Path to Age Estimation through DNA Methylation.International journal of molecular sciences · 2024Review
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundObesity, a major global health problem, is associated with increased cardiometabolic morbidity and mortality. Protein glycosylation is a frequent posttranslational modification, highly responsive to inflammation and ageing. The prospect of biological age reduction, by changing glycosylation patterns through metabolic intervention, opens many possibilities. We have investigated whether weight loss interventions affect inflammation- and ageing-associated IgG glycosylation changes, in a longitudinal cohort of bariatric surgery patients. To support potential findings, BMI-related glycosylation changes were monitored in a longitudinal twins cohort.
methodsIgG N-glycans were chromatographically profiled in 37 obese patients, subjected to low-calorie diet, followed by bariatric surgery, across multiple timepoints. Similarly, plasma-derived IgG N-glycan traits were longitudinally monitored in 1680 participants from the TwinsUK cohort.
resultsLow-calorie diet induced a marked decrease in the levels of IgG N-glycans with bisecting GlcNAc, whose higher levels are usually associated with ageing and inflammatory conditions. Bariatric surgery resulted in extensive alterations of the IgG N-glycome that accompanied progressive weight loss during 1-year follow-up. We observed a significant increase in digalactosylated and sialylated glycans, and a substantial decrease in agalactosylated and core fucosylated IgG N-glycans (adjusted p value range 7.38 × 10
conclusionsAltogether, these findings highlight that weight loss substantially affects IgG N-glycosylation, resulting in reduced glycan and biological age.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.