ArticleNature communications2021
Sex differences in fear memory consolidation via Tac2 signaling in mice.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- A Non-Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Unpredictable stress boosts perceptual learning and alters glucocorticoid and norepinephrine receptors in rats' dorsal hippocampus.Translational psychiatry · 2025Article
- Co-release of opposing signaling molecules controls the escalation and release of aggression.bioRxiv : the preprint server for biology · 2025Article
- Sex-specific differences in preclinical models of advanced chronic liver disease and portal hypertension.Biology of sex differences · 2025Article
- Integration of Glucagon-Like Peptide 1 Receptor Actions Through the Central Amygdala.Endocrinology · 2025Review
- A molecularly distinct cell type in the midbrain regulates intermale aggression behaviors in mice.Theranostics · 2025Article
- Loss of mGluMolecular psychiatry · 2024Article
- Sex differences in neural projections of fear memory processing in mice and humans.Science advances · 2024Article
- NK3R signalling in the posterodorsal medial amygdala is involved in stress-induced suppression of pulsatile LH secretion in female mice.Journal of neuroendocrinology · 2024Article
- 27-Hydroxycholesterol/liver X receptor/apolipoprotein E mediates zearalenone-induced intestinal immunosuppression: A key target potentially linking zearalenone and cancer.Journal of pharmaceutical analysis · 2024Article
- Threat gates visual aversion via theta activity in Tachykinergic neurons.Nature communications · 2023Article
- The estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling.Nature communications · 2022Article
- Article
- Cortical VIPJournal of molecular neuroscience : MN · 2022Article
- PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus.Nature communications · 2022Article
- Sex-specific regulation of inhibition and network activity by local aromatase in the mouse hippocampus.Nature communications · 2022Article
- Hippocampal Estrogen Signaling Mediates Sex Differences in Retroactive Interference.Biomedicines · 2022Article
- Nk3R blockade has sex-divergent effects on memory in mice.Biology of sex differences · 2022Article
- Anxiety and cognitive-related effects of ΔPsychopharmacology · 2022Article
- Sex-Specific Neural Networks of Cued Threat Conditioning: A Pilot Study.Frontiers in systems neuroscience · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memory formation is key for brain functioning. Uncovering the memory mechanisms is helping us to better understand neural processes in health and disease. Moreover, more specific treatments for fear-related disorders such as posttraumatic stress disorder and phobias may help to decrease their negative impact on mental health. In this line, the Tachykinin 2 (Tac2) pathway in the central amygdala (CeA) has been shown to be sufficient and necessary for the modulation of fear memory consolidation. CeA-Tac2 antagonism and its pharmacogenetic temporal inhibition impair fear memory in male mice. Surprisingly, we demonstrate here the opposite effect of Tac2 blockade on enhancing fear memory consolidation in females. Furthermore, we show that CeA-testosterone in males, CeA-estradiol in females and Akt/GSK3β/β-Catenin signaling both mediate the opposite-sex differential Tac2 pathway regulation of fear memory.
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