ArticleNature communications2021
Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Untargeted and Targeted Liquid Chromatography-Mass Spectrometry-Based Lipidomic Profiling Revealed a Potential Biomarker Panel to Distinguish Clinical Isolates of M. tuberculosis From Nontuberculous M. kansasii.Pulmonary medicine · 2026Article
- Clinical emergence of inducible macrolide resistance mediated by acquiredAntimicrobial agents and chemotherapy · 2025Article
- Article
- Lenvatinib-Associated Non-Tuberculous Mycobacterial Pulmonary Disease: A Case Report.Respirology case reports · 2025Article
- Genomic-based genotype and drug susceptibility profile ofFrontiers in microbiology · 2025Article
- Evaluation of a Commercial Multiplex Real-Time PCR with Melting Curve Analysis for the Detection ofMicroorganisms · 2024Article
- The Intriguing Pattern of Nontuberculous Mycobacteria in Bulgaria and Description ofInternational journal of molecular sciences · 2024Article
- Mycobacteria that cause tuberculosis have retained ancestrally acquired genes for the biosynthesis of chemically diverse terpene nucleosides.PLoS biology · 2024Article
- Phylogeographic Analysis of Mycobacterium kansasii Isolates from Patients with M. kansasii Lung Disease in Industrialized City, Taiwan.Emerging infectious diseases · 2024Article
- Phylogenomic and genomic analysis reveals unique and shared genetic signatures ofMicrobial genomics · 2024Article
- Detection of Mtb and NTM: preclinical validation of a new asymmetric PCR-binary deoxyribozyme sensor assay.Microbiology spectrum · 2024Article
- Article
- Ongoing evolution of the Mycobacterium tuberculosis lactate dehydrogenase reveals the pleiotropic effects of bacterial adaption to host pressure.PLoS pathogens · 2024Article
- Extended water stagnation in buildings during the COVID-19 pandemic increases the risks posed by opportunistic pathogens.Water research X · 2023Article
- Mutational spectra are associated with bacterial niche.Nature communications · 2023Article
- Whole-genome sequencing provides insights into a novel species:Microbiology spectrum · 2023Article
- Multiple Bone Destruction Secondary toDiagnostics (Basel, Switzerland) · 2023Article
- Galleria mellonella-intracellular bacteria pathogen infection models: the ins and outs.FEMS microbiology reviews · 2023Review
- Treatment of non-tuberculosis mycobacteria skin infections.Frontiers in pharmacology · 2023Review
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Authors and funding
24 authors at 13 institutions in 5 countries.
Funding
Abstract
Mycobacterium kansasii can cause serious pulmonary disease. It belongs to a group of closely-related species of non-tuberculous mycobacteria known as the M. kansasii complex (MKC). Here, we report a population genomics analysis of 358 MKC isolates from worldwide water and clinical sources. We find that recombination, likely mediated by distributive conjugative transfer, has contributed to speciation and on-going diversification of the MKC. Our analyses support municipal water as a main source of MKC infections. Furthermore, nearly 80% of the MKC infections are due to closely-related M. kansasii strains, forming a main cluster that apparently originated in the 1900s and subsequently expanded globally. Bioinformatic analyses indicate that several genes involved in metabolism (e.g., maintenance of the methylcitrate cycle), ESX-I secretion, metal ion homeostasis and cell surface remodelling may have contributed to M. kansasii's success and its ongoing adaptation to the human host.
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