Evidence map›Paper›PMID 33941618›Full record

ArticleMolecular and cellular biology2021

Defining Key Residues of the Swi1 Prion Domain in Prion Formation and Maintenance.

Dustin K Goncharoff, Raudel Cabral, Sarah V Applebey, Manasa Pagadala, Zhiqiang Du, Liming Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Mapping of Prion Structures in the Yeast Rnq1.International journal of molecular sciences · 2024
    Article
  4. How Big Is the Yeast Prion Universe?International journal of molecular sciences · 2023
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dustin K GoncharoffDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Raudel CabralDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Sarah V ApplebeyDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Manasa PagadalaDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Zhiqiang DuDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Liming LiDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Funding

Prion-mediated protein aggregation/co-aggregation and cellular consequenceR01GM126318 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DU, ZHIQIANG · 2018 to 2022
$1.6M
High Throughput Screening for Small-molecules Facilitating Prion StudyR01GM110045 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LI, LIMING · 2014 to 2016
$866k
NIGMS NIH HHS R01 GM110045NIGMS NIH HHS R01 GM126318
6 · The paper itself

Abstract

Prions are self-perpetuating, alternative protein conformations associated with neurological diseases and normal cellular functions. Saccharomyces cerevisiae contains many endogenous prions, providing a powerful system to study prionization. Previously, we demonstrated that Swi1, a component of the SWI/SNF chromatin-remodeling complex, can form the prion [

Indexed as

Chromatin Assembly and DisassemblyChromosomal Proteins, Non-HistoneChromosomesGene Expression Regulation, FungalMutationPrionsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsChromosomal Proteins, Non-HistonePrionsSaccharomyces cerevisiae ProteinsSWI1 protein, S cerevisiaeTranscription Factorsprion domainprionogenesisprotein aggregationSaccharomyces cerevisiae[SWI+]Swi1SWI/SNFyeast

Identifiers

PMID33941618
PMCPMC8224238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.