Evidence map›Paper›PMID 33941576›Full record

ArticleInfection and immunity2021

Th17 Cells Provide Mucosal Protection against Gastric Trypanosoma cruzi Infection.

Catherine W Cai, Christopher S Eickhoff, Krystal A Meza, Jennifer R Blase, Rebecca E Audette, David H Chan, Kevin A Bockerstett, Richard J DiPaolo, Daniel F Hoft

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Galectin-8 deficiency promotes chronic splenomegaly persistence in Chagas disease.Frontiers in cellular and infection microbiology · 2025
    Article
  3. Article
  4. Article
  5. Macrophages in immunoregulation and therapeutics.Signal transduction and targeted therapy · 2023
    Review
  6. Review
  7. Recombinant antigen P29 ofFrontiers in immunology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Catherine W CaiDivision of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
Christopher S EickhoffDivision of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
Krystal A MezaDivision of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
Jennifer R BlaseDivision of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
Rebecca E AudetteDivision of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
David H ChanDivision of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
Kevin A BockerstettDepartment of Molecular Microbiology & Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
Richard J DiPaoloDepartment of Molecular Microbiology & Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
Daniel F HoftDivision of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
Saint Louis University · US

Funding

Protective and pathologic effects of Th17 cells specific for an intracellular pathogenR21AI128270 · NIAID · SAINT LOUIS UNIVERSITY · PI HOFT, DANIEL F. · 2017 to 2018
$417k
The Role of Epstein-Barr Virus-Induced Gene 3 (EBI3) in Preventing Gastric Atrophy and MetaplasiaF30DK118873 · NIDDK · SAINT LOUIS UNIVERSITY · PI BOCKERSTETT, KEVIN A · 2018 to 2021
$157k
American Heart Association (AHA) 17CPRE33680012HHS | National Institutes of Health (NIH) 5R21AI128270NIAID NIH HHS R21 AI128270NIDDK NIH HHS F30 DK118873
6 · The paper itself

Abstract

Trypanosoma cruzi is the intracellular parasite of Chagas disease, a chronic condition characterized by cardiac and gastrointestinal morbidity. Protective immunity requires CD4

Indexed as

Immunity, MucosalAnimalsChagas DiseaseDisease Models, AnimalGastric MucosaHost-Parasite InteractionsInterleukin-17Lymphocyte ActivationMacrophagesMiceMice, KnockoutNADPH OxidasesTh17 CellsTrypanosoma cruziInterleukin-17NADPH OxidasesChagas diseaseIL-17IL-17ANADPH oxidaseneglected tropical diseasesparasitologyreactive oxygen speciesTh17 cellsTrypanosoma cruzi

Identifiers

PMID33941576
PMCPMC8208511
OpenAlexW3159476554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.