Evidence map›Paper›PMID 33941516›Full record

ArticleAntimicrobial agents and chemotherapy2021

Tafenoquine Is a Promising Drug Candidate for the Treatment of Babesiosis.

Mingming Liu, Shengwei Ji, Daisuke Kondoh, Eloiza May Galon, Jixu Li, Mizuki Tomihari, Masashi Yanagawa, Michihito Tagawa, Mami Adachi, Masahito Asada and 3 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Tafenoquine: A Breakthrough Option for Babesiosis Treatment.Tropical medicine and infectious disease · 2026
    Article
  3. Review
  4. Human babesiosis: The past, present and future.Expert reviews in molecular medicine · 2025
    Review
  5. Article
  6. Efficacy of tafenoquine in dogs naturally infected with Babesia gibsoni.The Journal of veterinary medical science · 2025
    Article
  7. Vesicular mechanisms of drug resistance in apicomplexan parasites.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  8. Review
  9. Article
  10. Tafenoquine for Relapsing Babesiosis: A Case Series.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  11. Article
  12. Comparative chemical genomics inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Review
  15. Article
  16. Serum metabolomic profiles in BALB/c mice induced byFrontiers in cellular and infection microbiology · 2023
    Article
  17. Efficacy of the Antimalarial MMV390048 againstAntimicrobial agents and chemotherapy · 2022
    Article
  18. Article
  19. Phosphatidylinositol 4-kinase is a viable target for the radical cure ofFrontiers in cellular and infection microbiology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Mingming LiuNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Shengwei JiNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Daisuke KondohDepartment of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Eloiza May GalonNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Jixu LiNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Mizuki TomihariDepartment of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Masashi YanagawaDepartment of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Michihito TagawaDepartment of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Mami AdachiDepartment of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Masahito AsadaNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Ikuo IgarashiNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Aiko IguchiJoint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, Japan.
Xuenan XuanNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Obihiro University of Agriculture and Veterinary Medicine · JPTottori University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to drug resistance, commonly used anti-

Indexed as

BabesiosisPharmaceutical PreparationsAminoquinolinesAnimalsDogsMiceMice, Inbred BALB CMice, SCIDAminoquinolinesPharmaceutical Preparationstafenoquinebabesiosisimmunocompromisedoxidative stresstafenoquine

Identifiers

PMID33941516
PMCPMC8373227
OpenAlexW3157193308

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.