Evidence map›Paper›PMID 33941254›Full record

ArticleAlzheimer's research & therapy2021

Investigating the relationship between BMI across adulthood and late life brain pathologies.

Christopher A Lane, Josephine Barnes, Jennifer M Nicholas, John W Baker, Carole H Sudre, David M Cash, Thomas D Parker, Ian B Malone, Kirsty Lu, Sarah-Naomi James and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 6 institutions in 2 countries.

Christopher A LaneDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, Box 16, Queen Square, London, WC1N 3BG, UK.
Josephine BarnesDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, Box 16, Queen Square, London, WC1N 3BG, UK.
Jennifer M NicholasDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, Box 16, Queen Square, London, WC1N 3BG, UK.
John W BakerDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, Box 16, Queen Square, London, WC1N 3BG, UK.ORCID 0000-0002-8543-5518
Carole H SudreDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, Box 16, Queen Square, London, WC1N 3BG, UK.
David M CashDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, Box 16, Queen Square, London, WC1N 3BG, UK.
Thomas D ParkerDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, Box 16, Queen Square, London, WC1N 3BG, UK.
Ian B MaloneDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, Box 16, Queen Square, London, WC1N 3BG, UK.
Kirsty LuDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, Box 16, Queen Square, London, WC1N 3BG, UK.
Sarah-Naomi JamesMRC Unit for Lifelong Health and Ageing at UCL, London, UK.
Ashvini KeshavanDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, Box 16, Queen Square, London, WC1N 3BG, UK.
Sarah BuchananDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, Box 16, Queen Square, London, WC1N 3BG, UK.
Sarah KeussDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, Box 16, Queen Square, London, WC1N 3BG, UK.
Heidi Murray-SmithDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, Box 16, Queen Square, London, WC1N 3BG, UK.
Andrew WongMRC Unit for Lifelong Health and Ageing at UCL, London, UK.
Elizabeth GordonDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, Box 16, Queen Square, London, WC1N 3BG, UK.
William CoathDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, Box 16, Queen Square, London, WC1N 3BG, UK.
Marc ModatDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, Box 16, Queen Square, London, WC1N 3BG, UK.
David ThomasLeonard Wolfson Experimental Neurology Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Rebecca HardyMRC Unit for Lifelong Health and Ageing at UCL, London, UK.
Marcus Richards *MRC Unit for Lifelong Health and Ageing at UCL, London, UK.
Nick C Fox *Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, Box 16, Queen Square, London, WC1N 3BG, UK.
Jonathan M Schott *Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, Box 16, Queen Square, London, WC1N 3BG, UK. j.schott@ucl.ac.uk.
National Hospital for Neurology and Neurosurgery · GBMRC Unit for Lifelong Health and Ageing · GBKing's College London · GBUK Dementia Research Institute · GBRoche (Estonia) · EEUniversity of London · GB

Funding

Alzheimer's Research UK ARUK-PG2014-1946Alzheimer's Research UK ARUK-PG2017-1946Medical Research Council MC_UU_00019/2Medical Research Council MC_UU_00019/3Medical Research Council MC_UU_00019/4Medical Research Council MC_UU_12019/1Medical Research Council MC_UU_12019/2Medical Research Council MC_UU_12019/3MRF_ CSUB199166MRF_ MC_UU_12019/1, MC_UU_12019/2, MC_UU_12019/3
6 · The paper itself

Abstract

backgroundIn view of reported associations between high adiposity, particularly in midlife and late-life dementia risk, we aimed to determine associations between body mass index (BMI), and BMI changes across adulthood and brain structure and pathology at age 69-71 years.

methodsFour hundred sixty-five dementia-free participants from Insight 46, a sub-study of the British 1946 birth cohort, who had cross-sectional T1/FLAIR volumetric MRI, and florbetapir amyloid-PET imaging at age 69-71 years, were included in analyses. We quantified white matter hyperintensity volume (WMHV) using T1 and FLAIR 3D-MRI; β-amyloid (Aβ) positivity/negativity using a SUVR approach; and whole brain (WBV) and hippocampal volumes (HV) using 3D T1-MRI. We investigated the influence of BMI, and BMI changes at and between 36, 43, 53, 60-64, 69 and 71 years, on late-life WMHV, Aβ-status, WBV and mean HV. Analyses were repeated using overweight and obese status.

resultsAt no time-point was BMI, change in BMI or overweight/obese status associated with WMHV or WBV at age 69-71 years. Decreasing BMI in the 1-2 years before imaging was associated with an increased odds of being β-amyloid positive (OR 1.45, 95% confidence interval 1.09, 1.92). There were associations between being overweight and larger mean HV at ages 60-64 (β = 0.073 ml, 95% CI 0.009, 0.137), 69 (β = 0.076 ml, 95% CI 0.012, 0.140) and 71 years (β = 0.101 ml, 95% CI 0.037, 0.165). A similar, albeit weaker, trend was seen with obese status.

conclusionsUsing WMHV, β-amyloid status and brain volumes as indicators of brain health, we do not find evidence to explain reported associations between midlife obesity and late-life dementia risk. Declining BMI in later life may reflect preclinical Alzheimer's disease.

Indexed as

Alzheimer DiseaseAdultAgedAmyloid beta-PeptidesBody Mass IndexBrainCross-Sectional StudiesHumansMiddle AgedAmyloid beta-PeptidesAlzheimer’s diseaseCohort studiesEpidemiologyMRIPET

Identifiers

PMID33941254
PMCPMC8091727
OpenAlexW3159282112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.