ArticleJournal of orthopaedic surgery and research2021
Clinical characteristics and risk factors for culture-negative periprosthetic joint infections.
Article in Journal of orthopaedic surgery and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Comparative diagnostic accuracy of next-generation sequencing in different specimen types for periprosthetic joint infection: A systematic review and meta-analysis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Pooled it
- Comparable clinical outcomes of culture-negative and culture-positive periprosthetic joint infections: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2023Pooled it
- Diagnostic Value of Synovial Fluid Biomarkers for Periprosthetic Joint Infection: A Prospective, Double-blind Trial.Medical science monitor : international medical journal of experimental and clinical research · 2023Trial
- A model for predicting the likelihood of negative culture results in children with osteoarticular infections.European journal of medical research · 2026Article
- Integrated Single-Cell and Bulk RNA Sequencing Reveals the Diagnostic Value of Synovial Tissue Calprotectin and the MDSC-Associated Immune Microenvironment in Periprosthetic Joint Infection.Infection and drug resistance · 2026Article
- Management and outcomes of culture-negative periprosthetic joint infection: a systematic review and meta-analysis.Journal of bone and joint infection · 2026Article
- Article
- Clinical application of synovial fluid albumin-to-globulin ratio as a novel biomarker in diagnosing chronic periprosthetic joint infection.Frontiers in cellular and infection microbiology · 2026Article
- High sensitivity and enhanced antibiotic stewardship of the BioFire Joint Infection Panel in acute, but not chronic, prosthetic joint infection of the knee.Microbiology spectrum · 2025Article
- Organism profiles and empirical treatments for periprosthetic joint infections.Journal of orthopaedic surgery and research · 2025Article
- Agreement Analysis Among Hip and Knee Periprosthetic Joint Infections Classifications.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Analysis of Serum and Synovial Inflammatory Markers in Periprosthetic Joint Infections: A Narrative Review.Cureus · 2024Review
- Development of an automated amplicon-based next-generation sequencing pipeline for rapid detection of bacteria and fungi directly from clinical specimens.Journal of clinical microbiology · 2024Article
- Culture-negative periprosthetic joint infections: Do we have an issue?Journal of clinical orthopaedics and trauma · 2024Article
- Accuracy of Albumin, Globulin, and Albumin-Globulin Ratio for Diagnosing Periprosthetic Joint Infection: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Global Cluster Analysis and Network Visualization in Prosthetic Joint Infection: A Scientometric Mapping.Orthopaedic surgery · 2023Article
- Molecular Approach for the Laboratory Diagnosis of Periprosthetic Joint Infections.Microorganisms · 2022Review
- A comparsion study between debridement, antibiotics, and implant retention and two-stage revision total knee arthroplasty for the management of periprosthetic joint infection occurring within 12 weeks from index total knee arthroplasty.Journal of orthopaedic surgery and research · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCulture-negative periprosthetic joint infections (PJIs) can complicate diagnosis and management of PJI. This study aimed to identify risk factors for culture-negative PJI and differences in clinical characteristics between culture-positive and culture-negative PJI group.
methodsThis retrospective, cross-sectional study evaluated PJI cases obtained between January 2013 and October 2019 at our institution. These PJI cases were divided into culture-positive and culture-negative groups and then compared. The demographics, laboratory findings, and details of patient's clinical characteristics were investigated. Univariate and multivariate logistic regression analysis were performed to investigate risk factors for culture-negative PJI.
resultsA total of 109 PJI cases were included in the analysis: 82 (75%) culture-positive and 27 (25%) culture-negative. The mean serum white blood cell (WBC) count, C-reactive protein level, and erythrocyte sedimentation rate in the culture-negative group were significantly lower than those in the culture-positive group (p < 0.05). There were no significant differences between the two groups regarding history of prior antibacterial administration or treatment success rates. Multivariate analysis identified a low serum WBC count as a risk factor for culture-negative PJI (odds ratio = 0.78; 95% confidence interval [CI] = 0.63-0.97; p = 0.027).
conclusionsA low serum WBC count is a risk factor for culture-negative PJI, but prior antimicrobial therapy is not. The results suggest that PJI cases with lower levels of systemic inflammation are likely to be culture-negative; therefore, the possibility of a culture-negative result should be considered in suspected cases of PJI with low inflammatory markers, regardless of prior antibiotic exposure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.