ArticleThe Journal of the Acoustical Society of America2021
Mouse middle-ear forward and reverse acoustics.
Article in The Journal of the Acoustical Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Article
- Simulation-based inference for subject-specific tuning of middle ear finite-element models towards personalized objective diagnosis.Scientific reports · 2025Article
- Acoustical Effects of Tympanostomy Tube Attachment to Human Tympanic Membrane.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- From Simulations to Inference: Using Machine Learning to Tune Patient-Specific Finite-Element Models of the Middle Ear Towards Objective Diagnosis.bioRxiv : the preprint server for biology · 2024Article
- The influence of tympanic-membrane orientation on acoustic ear-canal quantities: A finite-element analysis.The Journal of the Acoustical Society of America · 2024Article
- Finite-Element Modelling Based on Optical Coherence Tomography and Corresponding X-ray MicroCT Data for Three Human Middle Ears.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Stimulus-frequency otoacoustic emissions and middle-ear pressure gains in a finite-element mouse model.The Journal of the Acoustical Society of America · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The mouse is an important animal model for hearing science. However, our knowledge of the relationship between mouse middle-ear (ME) anatomy and function is limited. The ME not only transmits sound to the cochlea in the forward direction, it also transmits otoacoustic emissions generated in the cochlea to the ear canal (EC) in the reverse direction. Due to experimental limitations, a complete characterization of the mouse ME has not been possible. A fully coupled finite-element model of the mouse EC, ME, and cochlea was developed and calibrated against experimental measurements. Impedances of the EC, ME, and cochlea were calculated, alongside pressure transfer functions for the forward, reverse, and round-trip directions. The effects on sound transmission of anatomical changes such as removing the ME cavity, pars flaccida, and mallear orbicular apophysis were also calculated. Surprisingly, below 10 kHz, the ME cavity, eardrum, and stapes annular ligament were found to significantly affect the cochlear input impedance, which is a result of acoustic coupling through the round window. The orbicular apophysis increases the delay of the transmission line formed by the flexible malleus, incus, and stapes, and improves the forward sound-transmission characteristics in the frequency region of 7-30 kHz.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.