Evidence map›Paper›PMID 33940135›Full record

ArticleMicrobial pathogenesis2021

GrgA overexpression inhibits Chlamydia trachomatis growth through sigma

Wurihan Wurihan, Alec M Weber, Zheng Gong, Zhongzi Lou, Samantha Sun, Jizhang Zhou, Huizhou Fan

Abstract read
In one paragraph

Article in Microbial pathogenesis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Infection and immunity · 2025
    Article
  6. bioRxiv : the preprint server for biology · 2024
    Article
  7. Article
  8. Requirement of GrgA forbioRxiv : the preprint server for biology · 2023
    Article
  9. Article
  10. Robust Heat Shock Response inFrontiers in microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wurihan WurihanDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers The State University of New Jersey, Piscataway, NJ, 08854, USA.
Alec M WeberDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers The State University of New Jersey, Piscataway, NJ, 08854, USA.
Zheng GongDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers The State University of New Jersey, Piscataway, NJ, 08854, USA.
Zhongzi LouDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers The State University of New Jersey, Piscataway, NJ, 08854, USA; Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Samantha SunDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers The State University of New Jersey, Piscataway, NJ, 08854, USA.
Jizhang ZhouLanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Huizhou FanDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers The State University of New Jersey, Piscataway, NJ, 08854, USA. Electronic address: huizhou.fan@rutgers.edu.

Funding

GrgA:a Multifunctional Transcription Factor that Control Chlamydial Gene ExpressionR21AI140167 · NIAID · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI FAN, HUIZHOU · 2019 to 2020
$435k
Exploration of SF3 as a Chemical Probe for Chlamydial BiologyR21AI154305 · NIAID · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI FAN, HUIZHOU · 2020 to 2021
$431k
GrgA: Key Regulator of Chlamydial Physiology and potential Antichlamydial TargetR21AI122034 · NIAID · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI FAN, HUIZHOU · 2016 to 2017
$414k
NIAID NIH HHS R21 AI122034NIAID NIH HHS R21 AI140167NIAID NIH HHS R21 AI154305
6 · The paper itself

Abstract

The obligate intracellular bacterium Chlamydia trachomatis is an important human pathogen with a biphasic developmental cycle comprised of an infectious elementary body (EB) and a replicative reticulate body (RB). Whereas σ

Indexed as

Chlamydia trachomatisGene Expression Regulation, BacterialBacterial ProteinsHumansSigma FactorTranscription FactorsBacterial ProteinsSigma FactorTranscription FactorsChlamydiaCT504CTL0766GrgASigma 28Sigma 66

Identifiers

PMID33940135
PMCPMC8187326

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.