Evidence map›Paper›PMID 33940087›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2021

Manuel Röhrich, Mustafa Syed, Dawn P Liew, Frederik L Giesel, Jakob Liermann, Peter L Choyke, Annika K Wefers, Thomas Ritz, Marina Szymbara, Lisa Schillings and 9 more

Open access · greenAbstract read
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Utilization ofQuantitative imaging in medicine and surgery · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Molecular imaging and radionuclide therapy · 2024
    Article
  11. Diagnostic Potential of Supplemental Static and DynamicJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  12. Article
  13. Immunohistochemical FAP Expression ReflectsJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  14. Case report: [American journal of nuclear medicine and molecular imaging · 2024
    Article
  15. Diagnostic Accuracy of [Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  16. Impact ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  17. Article
  18. FAPI PET/CT Imaging-An Updated Review.Diagnostics (Basel, Switzerland) · 2023
    Review
  19. Article
  20. [Positron emission tomography in CUP syndrome].Radiologie (Heidelberg, Germany) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Manuel RöhrichDepartment of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany. Electronic address: manuel.roehrich@med.uni-heidelberg.de.
Mustafa SyedDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany.
Dawn P LiewDepartment of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany.
Frederik L GieselDepartment of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany; German Cancer Consortium (DKTK), partner site Heidelberg, Germany.
Jakob LiermannDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany.
Peter L ChoykeMolecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA.
Annika K WefersDepartment of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.
Thomas RitzInstitute of Pathology, University Hospital Heidelberg, Germany.
Marina SzymbaraClinical Cooperation Unit Molecular and Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Lisa SchillingsDepartment of Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Ulrike HegerDepartment of Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Hendrik RathkeDepartment of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany.
Clemens KratochwilDepartment of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany.
Peter E HuberDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany; Clinical Cooperation Unit Molecular and Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Andreas von DeimlingDepartment of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jürgen DebusDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany; National Center for Tumor Diseases (NCT), Heidelberg, Germany; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Hans-Ulrich KauczorDepartment of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg, Member of the German Center for Lung Research DZL, Heidelberg, Germany.
Uwe HaberkornDepartment of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany; German Cancer Consortium (DKTK), partner site Heidelberg, Germany; Translational Lung Research Center Heidelberg, Member of the German Center for Lung Research DZL, Heidelberg, Germany; Clinical Cooperation Unit, Department of Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sebastian AdebergDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany.
Heidelberg University · DEGerman Cancer Research Center · DENational Institutes of Health · USUniversität Hamburg · DE

Funding

Growth Factor Imaging and PhotoimmunotherapyZIABC010656 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHOYKE, PETER L · 2009 to 2024
$31.6M
Intracellular In vivo ImagingZIABC010657 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHOYKE, PETER L · 2009 to 2025
$20.3M
Intramural NIH HHS ZIA BC010656
6 · The paper itself

Abstract

backgroundAdenoid cystic carcinomas (ACCs) are rare epithelial tumors mostly situated in the head and neck region and characterized by infiltrative growth. The tumor stroma of ACCs includes cancer-associated fibroblasts (CAFs) expressing Fibroblast Activation Protein (FAP), a new target for positron emission tomography (PET) imaging. Here we describe the value of PET/ computed tomography (PET/CT) imaging using PATIENTS AND

methodsPatients underwent contrast enhanced staging CT (ceCT) and magnetic resonance imaging (ceMRI) before

resultsWe observed elevated tracer uptake in all ACCs. Immunohistochemistry showed FAP-expressing CAFs in the tumor. Compared to conventional staging,

conclusion

Indexed as

Carcinoma, Adenoid CysticPositron Emission Tomography Computed TomographyGallium RadioisotopesHumansPositron-Emission TomographyGallium RadioisotopesACCAdenoid cystic carcinomaFAPFibroblast Activation ProteinPositron Emission TomographyRadiotherapy

Identifiers

PMID33940087
PMCPMC9913884
OpenAlexW3159514541

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.