ArticleJournal of the American Chemical Society2021
Bright Chromenylium Polymethine Dyes Enable Fast, Four-Color
Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
60 citing papers in PubMed, 169 citations in OpenAlex.
- NIR-II squeezed light-field microscopy enables high-speed volumetric imaging of deep-tissue dynamicsbioRxiv : the preprint server for biology · 2026Article
- Structural Engineering of Cyanine Dyes to Access Shortwave Infrared-Emissive J-Aggregates.Journal of the American Chemical Society · 2026Article
- Silicon Flavylium Polymethine Dyes for Shortwave Infrared Imaging.Journal of the American Chemical Society · 2026Article
- Fluorescent J‑Aggregates in the NIR-II Window: Unlocking Frontiers in Biomedical Imaging.Chemical & biomedical imaging · 2026Review
- Near-Infrared and Shortwave Infrared Building Blocks for Activity-Based Sensors in Animals.Bioconjugate chemistry · 2026Review
- De Novo Design of Near-Infrared Fluorescence-Activating Proteins.Journal of the American Chemical Society · 2026Article
- Review: structural determinants of organic dyes for controlling biological clearance pathways.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Review
- Donor-Acceptor Pentacene Analogues With Near-Infrared Emission and Tunable Aromaticity.Angewandte Chemie (International ed. in English) · 2026Article
- Chromenylium and Flavylium Polymethine Fluorophores Light Up the Shortwave Infrared Region.Accounts of chemical research · 2026Article
- Extended Fused Carbazole-BODIPY, High Brightness NIR Organic Dyes.Angewandte Chemie (International ed. in English) · 2026Article
- Trinuclear Heptamethine Dyes for Shortwave Infrared In Vivo Imaging.Angewandte Chemie (International ed. in English) · 2026Article
- Chemical fluorophores for fluorescence lifetime imaging.Chemical Society reviews · 2026Review
- High-resolution in vivo kinematic tracking with customized injectable fluorescent nanoparticles.Science advances · 2025Article
- The latest developments of near-infrared fluorescent probes from NIR-I to NIR-II for bioimaging.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Review
- Near-infrared II cyanine fluorophores with large stokes shift engineered by regulating respective absorption and emission.Nature communications · 2025Article
- Palladium-Catalyzed Functionalization of Shortwave Infrared Heptamethine Fluorophores Expands Their In Vivo Utility.JACS Au · 2025Article
- High-Resolution Multicolor Shortwave Infrared DynamicJournal of the American Chemical Society · 2025Article
- Multi-stimuli-responsive polymers enabled by bio-inspired dynamic equilibria of flavylium chemistry.Chemical science · 2025Article
- Mixed-Layered Glycodendrimer Probe for Imaging Inflammation at Surgical Site Infections.ACS sensors · 2025Article
- Chromenylium Star Polymers: Merging Water Solubility and Stealth Properties with Shortwave Infrared Emissive Fluorophores.ACS central science · 2025Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Optical imaging within the shortwave infrared (SWIR, 1000-2000 nm) region of the electromagnetic spectrum has enabled high-resolution and high-contrast imaging in mice, non-invasively. Polymethine dyes, with their narrow absorption spectra and high absorption coefficients, are optimal probes for fast and multiplexed SWIR imaging. Here, we expand upon the multiplexing capabilities in SWIR imaging by obtaining brighter polymethine dyes with varied excitation wavelengths spaced throughout the near-infrared (700-1000 nm) region. Building on the flavylium polymethine dye scaffold, we explored derivatives with functional group substitution at the 2-position, deemed chromenylium polymethine dyes. The reported dyes have reduced nonradiative rates and enhanced emissive properties, enabling non-invasive imaging in mice in a single color at 300 fps and in three colors at 100 fps. Combined with polymethine dyes containing a red-shifted julolidine flavylium heterocycle and indocyanine green, distinct channels with well-separated excitation wavelengths provide non-invasive video-rate
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.