Evidence map›Paper›PMID 33939772›Full record

ArticleFunction (Oxford, England)2021

Gut Microbiota Represent a Major Thermogenic Biomass.

Ruth A Riedl, Colin M L Burnett, Nicole A Pearson, John J Reho, Mohamad Mokadem, Robert A Edwards, Tammy L Kindel, John R Kirby, Justin L Grobe

Open access · goldAbstract read
In one paragraph

Article in Function (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Sleeve gastrectomy protects lean mice from future obesity.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Unlocking the gut: microbiome's role in energy metabolism.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  10. Angiotensin ATiScience · 2025
    Article
  11. Gut microbial contributions to thermogenesis.The Journal of experimental biology · 2025
    Review
  12. Reutericyclin mitigates risperidone-induced suppression of anaerobic energy expenditure.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  13. Article
  14. Article
  15. Early-life sodium deprivation programs long-term changes in ingestive behaviors and energy expenditure in C57BL/6J mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Article
  16. 360-Degree Perspectives on Obesity.Medicina (Kaunas, Lithuania) · 2023
    Review
  17. Article
  18. Review
  19. Gut physiology meets microbiome science.Gut microbiome (Cambridge, England) · 2023
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Ruth A RiedlDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Colin M L BurnettDepartment of Internal Medicine, Division of Cardiology, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Nicole A PearsonDepartment of Laboratory Medicine and Pathology/Proteomics, Mayo Clinic, Rochester, MN, USA.
John J RehoDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Mohamad MokademDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Robert A EdwardsCollege of Science and Engineering, Flinders University, Adelaide, South Australia, Australia.
Tammy L KindelDepartment of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
John R KirbyCardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, USA.
Justin L GrobeDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0001-9737-0873
Medical College of Wisconsin · USUniversity of Iowa Hospitals and Clinics · USBaylor College of Medicine · USFlinders University · AUMayo Clinic · US

Funding

Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5M
Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2007 to 2022
$30.2M
Interaction between leptin and angiotensin in the pathogenesis of obesity-hypertensionR01HL134850 · NHLBI · UNIVERSITY OF IOWA · PI Justin L Grobe · 2017 to 2026
$4.4M
SHORT-TERM TRAINING: STUDENTS IN HEALTH PROF. SCHOOLST35HL007485 · NHLBI · UNIVERSITY OF IOWA · PI ROGHAIR, ROBERT D · 1985 to 2019
$4.3M
Lysine Acetylation in N. gonorrhoeae Quorum Sensing and Biofilm FormationR01AI108255 · NIAID · UNIVERSITY OF IOWA · PI KIRBY, JOHN R, SCHILLING, BIRGIT · 2014 to 2018
$4.1M
The role of GLP-1 in cardiac recovery after bariatric surgery in obesity-induced heart failureK08HL140000 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI KINDEL, TAMMY LYN · 2019 to 2022
$603k
NCATS NIH HHS UL1 TR001436NHLBI NIH HHS K08 HL140000NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R01 HL134850NHLBI NIH HHS T35 HL007485NIAID NIH HHS R01 AI108255
6 · The paper itself

Abstract

Evidence supports various roles for microbial metabolites in the control of multiple aspects of host energy flux including feeding behaviors, digestive efficiency, and energy expenditure, but few studies have quantified the energy utilization of the biomass of the gut microbiota itself. Because gut microbiota exist in an anoxic environment, energy flux is expected to be anaerobic; unfortunately, commonly utilized O

Indexed as

Gastrointestinal MicrobiomeMicrobiotaAnimalsBiomassMiceMice, Inbred C57BLWeight Gainenergygutmetabolismmicrobiomemicrobiota

Identifiers

PMID33939772
PMCPMC8055641
OpenAlexW3154460583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.